SPATS2-liki protein (spermatogenezi pridruženi, serin-bogati 2-liki protein) ili DNAPTP6 (DNK-polimerazno transaktivirtani protein 6) jest protein koji je kod ljudi kodiran genom SPATS2L sa hromosoma 2..[5][6]
Kratke činjenice Dostupne strukture, PDB ...
| SATB2 |
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| Identifikatori |
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| Aliasi | SATB2 |
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| Vanjski ID-jevi | OMIM: 608148 MGI: 2679336 HomoloGene: 32249 GeneCards: SATB2 |
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| Ontologija gena |
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| Molekularna funkcija | • sequence-specific DNA binding
• vezivanje sa DNK
• chromatin binding
• GO:0001948, GO:0016582 vezivanje za proteine
• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
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| Ćelijska komponenta | • histone deacetylase complex
• transcription regulator complex
• nuclear matrix
• jedro
• nukleoplazma
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| Biološki proces | • commitment of neuronal cell to specific neuron type in forebrain
• embryonic skeletal system morphogenesis
• cellular response to organic substance
• chromatin remodeling
• roof of mouth development
• GO:0009373 regulation of transcription, DNA-templated
• embryonic pattern specification
• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
• neuron migration
• GO:1901227 negative regulation of transcription by RNA polymerase II
• transcription, DNA-templated
• multicellular organism development
• cartilage development
• Regulacija ekspresije gena
• osteoblast development
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
• transcription by RNA polymerase II
• GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization
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| Izvori:Amigo / QuickGO |
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| Ortolozi |
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| Vrste | Čovjek | Miš |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNK) | | |
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| RefSeq (bjelančevina) | | |
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| Lokacija (UCSC) | Chr 2: 199.27 – 199.47 Mb | Chr 1: 56.83 – 57.02 Mb |
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| PubMed pretraga | [3] | [4] |
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| Wikipodaci |
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Zatvori
Dužina polipeptidnog lanca je 558 aminokiselina, a molekulska težina 6 729 Da.[7]
| 10 | | 20 | | 30 | | 40 | | 50 |
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| MAELNTHVNV | | KEKIYAVRSV | | VPNKSNNEIV | | LVLQQFDFNV | | DKAVQAFVDG |
| SAIQVLKEWN | | MTGKKKNNKR | | KRSKSKQHQG | | NKDAKDKVER | | PEAGPLQPQP |
| PQIQNGPMNG | | CEKDSSSTDS | | ANEKPALIPR | | EKKISILEEP | | SKALRGVTEG |
| NRLLQQKLSL | | DGNPKPIHGT | | TERSDGLQWS | | AEQPCNPSKP | | KAKTSPVKSN |
| TPAAHLEIKP | | DELAKKRGPN | | IEKSVKDLQR | | CTVSLTRYRV | | MIKEEVDSSV |
| KKIKAAFAEL | | HNCIIDKEVS | | LMAEMDKVKE | | EAMEILTARQ | | KKAEELKRLT |
| DLASQMAEMQ | | LAELRAEIKH | | FVSERKYDEE | | LGKAARFSCD | | IEQLKAQIML |
| CGEITHPKNN | | YSSRTPCSSL | | LPLLNAHAAT | | SGKQSNFSRK | | SSTHNKPSEG |
| KAANPKMVSS | | LPSTADPSHQ | | TMPANKQNGS | | SNQRRRFNPQ | | YHNNRLNGPA |
| KSQGSGNEAE | | PLGKGNSRHE | | HRRQPHNGFR | | PKNKGGAKNQ | | EASLGMKTPE |
| APAHSEKPRR | | RQHAADTSEA | | RPFRGSVGRV | | SQCNLCPTRI | | EVSTDAAVLS |
| VPAVTLVA |
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
