PRIC285

Interaktivni kompleks receptora A aktiviranog peroksisomskim proliferatorom 285 je ljudski gen.^[5]

PRIC285
Identifikatori
Aliasi	HELZ2
Vanjski ID-jevi	OMIM: 611265 MGI: 2385169 HomoloGene: 14118 GeneCards: HELZ2
Lokacija gena (čovjek) Hrom. Hromosom 20 (čovjek)[1] Bend 20q13.33 Početak 63,558,086 bp[1] Kraj 63,574,239 bp[1]
Lokacija gena (miš) Hrom. Hromosom 2 (miš)[2] Bend 2|2 H4 Početak 180,869,408 bp[2] Kraj 180,883,820 bp[2]
Ontologija gena Molekularna funkcija • vezivanje sa DNK • nucleotide binding • GO:0001948, GO:0016582 vezivanje za proteine • ATP binding • hydrolase activity • GO:0008026 helicase activity • nuclear receptor coactivator activity • vezivanje iona metala • vezivanje sa RNK • ribonuclease activity Ćelijska komponenta • membrana • jedro • nukleoplazma • citoplazma Biološki proces • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of lipid metabolic process • Nonsens-posredovano propadanje iRNK • RNA phosphodiester bond hydrolysis Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	85441	229003
Ensembl	ENSG00000130589	ENSMUSG00000027580
UniProt	Q9BYK8	E9QAM5
RefSeq (mRNK)	NM_001037335 NM_033405	NM_183162
RefSeq (bjelančevina)	NP_001032412 NP_208384	NP_898985
Lokacija (UCSC)	Chr 20: 63.56 – 63.57 Mb	Chr 2: 180.87 – 180.88 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Protein kojega kodira ovaj gen je jedarni transkripcijski koaktivator za receptor alfa aktiviran proliferatorom peroksisoma. Kodirani protein sadrži cinkov prst i helikazu koja je čini se dijelom kompleksa interakcije receptora alfa koji aktivira proliferator peroksisoma. Ovaj gen je član porodice gena DNK2/NAM7 helikaza. Za ovaj gen pronađene su alternativno prerađene varijante transkripta koje kodiraju različite izoforme.^[5]

Aminokiselinska sekvenca proteina

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MAVWEAEQLG		GLQRGDLLTP		PAPDGDGRTA		PLGQPPGAQL		YCPACLVTCH
SQEAFENHCA		SSEHAQMVAF		DQALPWEHRS		PPPGLSKFEL		CPKPDLCEYG
DACTKAHSAQ		ELQEWVRRTQ		AVELRGQAAW		QDGLVPYQER		LLAEYQRSSS
EVLVLAETLD		GVRVTCNQPL		MYQAQERKTQ		YSWTFAVHSE		EPLLHVALLK
QEPGADFSLV		APGLPPGRLY		ARGERFRVPS		STADFQVGVR		VQAASFGTFE
QWVVFDFGRR		PVLLQKLGLQ		LGQGRRPGPC		RNLALGHPEE		MERWHTGNRH
VVPGVERTAE		QTALMAKYKG		PALALEFNRS		SVASGPISPT		NYRQRMHQFL
YEEEAAQQQL		VAKLTLRGQV		FLKTALQTPA		LNMLFAPPGA		LYAEVPVPSS
LMPDTDQGFL		LGRAVSTALV		APVPAPDNTV		FEVRLERRAS		SEQALWLLLP
ARCCLALGLQ		PEARLVLEVQ		FQIDPMTFRL		WHQAVDTLPE		EQLVVPDLPT
CALPRPWSVP		PLRRGNRKQE		LAVALIAGWG		PGDGRRVPPL		LIYGPFGTGK
TYTLAMASLE		VIRRPETKVL		ICTHTNSAAD		IYIREYFHSH		VSGGHPEATP
LRVMYTDRPL		SQTDPVTLQY		CCLTDDRQAF		RPPTRAELAR		HRVVVTTTSQ
ARELRVPVGF		FSHILIDEAA		QMLECEALTP		LAYASHGTRL		VLAGDHMQVT
PRLFSVARAR		AAEHTLLHRL		FLCYQQETHE		VARQSRLVFH		ENYRCTDAIV
SFISRHFYVA		KGNPIHARGK		VPPHPRHYPL		MFCHVAGSPD		RDMSMASWLN
LAEIAQVVEK		VQEAYNTWPS		CWGGREQRCI		CVVSHGAQVS		ALRQELRRRD
LGQVSVGSFE		ILPGRQFRVV		VLSTVHTCQS		LLSPGALAPE		FFTDARVLNT
VLTRAQSQLV		VVGDAVALCS		FGACGKLWES		FIRECVERHS		VCPEGLSMEQ
VEQGVAQRRR		WPPRGTQAGA		AGNWEAAPEP		VGDLAEEQAA		VVTAMVKAEP
GDEALSPASR		DITATTAQTE		AAAAPAGDAV		KEDVVPGACA		AGAAAAAGVE
STEAEDAEAD		FWPWDGELNA		DDAILRELLD		ESQKVMVTVG		EDGLLDTVAR
PESLQQARLY		ENLPPAALRK		LLHAEPERYR		HCSFVPETFE		RASAIPLDDA
SSGPIQVRGR		LDCGMAFAGD		EVLVQLLSGD		KAPEGRLRGR		VLGVLKRKRH
ELAFVCRMDT		WDPRIMVPIN		GSVTKIFVAE		LKDPSQVPIY		SLRKGRLQRV
GLERLTAEAR		HSRLFWVQIV		LWRQGFYYPL		GIVREVLPEA		STWEQGLRIL
GLEYSLRVPP		SDQATITKVL		QKYHTELGRV		AGRREDCRAF		LTFTVDPQGA
CNLDDALSVR		DLGPRCEVAV		HITDVASFVP		RDGVLDVEAR		RQGAAFYAPG
REPVPMLPAS		LCQDVLSLLP		GRDRLAISLF		LTMEKASGQL		KSLRFAPSVV
QSDRQLSYEE		AEEVIRQHPG		AGRELPARLD		SVDACVVAAC		YFSRLLRRHR
LRSDCFYEQP		DEDGTLGFRA		AHIMVKEYMI		QFNRLVAEFL		VGSECTRTVT
PLRWQPAPRS		QQLKALCEKH		GDRVPLSLHL		GHHLHGGGGS		PPDTRLHLLA
SLWKQVQFAA		RTQDYEQMVD		LVTTDDMHPF		LAPAGRDLRK		ALERSAFGRC
ARGHQQQGGH		YSLQVDWYTW		ATSPIRRYLD		VVLQRQILLA		LGHGGSAYSA
RDIDGLCQAF		SLQHALAQSY		QRRARSLHLA		VQLKAQPLDK		LGFVVDVEAG
SRCFRLLFPS		NRETLPDPCP		VPYGSLQLAE		HPHALAGRPG		LRLLWRRRVY
SAQGSSPPLP		LPGTVPDPHT		LAVETALWKQ		LLELVELQRW		PEAAALIQEK
GEASQRRELV		QVQRSHCGHF		LEVARELGSG		DTLQVQLGTS		LQHGFLVPSP
QLWTVAPGFS		LCLEHVERPG		DCFSGRVYRA		PRDRYRDVDE		YACVWEPFCA
LESATGAVAE		NDSVTLQHLS		VSWEASRTPQ		GQLQGAFRLE		AAFLEENCAD
INFSCCYLCI		RLEGLPAPTA		SPRPGPSSLG		PGLNVDPGTY		TWVAHGQTQD
WDQERRADRQ		EAPRRVHLFV		HHMGMEKVPE		EVLRPGTLFT		VELLPKQLPD
LRKEEAVRGL		EEASPLVTSI		ALGRPVPQPL		CRVIPSRFLE		RQTYNIPGGR
HKLNPSQNVA		VREALEKPFT		VIQGPPGTGK		TIVGLHIVFW		FHKSNQEQVQ
PGGPPRGEKR		LGGPCILYCG		PSNKSVDVLA		GLLLRRMELK		PLRVYSEQAE
ASEFPVPRVG		SRKLLRKSPR		EGRPNQSLRS		ITLHHRIRQA		PNPYSSEIKA
FDTRLQRGEL		FSREDLVWYK		KVLWEARKFE		LDRHEVILCT		CSCAASASLK
ILDVRQILVD		EAGMATEPET		LIPLVQFPQA		EKVVLLGDHK		QLRPVVKNER
LQNLGLDRSL		FERYHEDAHM		LDTQYRMHEG		ICAFPSVAFY		KSKLKTWQGL
RRPPSVLGHA		GKESCPVIFG		HVQGHERSLL		VSTDEGNENS		KANLEEVAEV
VRITKQLTLG		RTVEPQDIAV		LTPYNAQASE		ISKALRREGI		AGVAVSSITK
SQGSEWRYVL		VSTVRTCAKS		DLDQRPTKSW		LKKFLGFVVD		PNQVNVAVTR
AQEGLCLIGD		HLLLRCCPLW		RSLLDFCEAQ		QTLVPAGQVR		VCRRPTMPS

Reference

1. GRCh38: Ensembl release 89: ENSG00000130589 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027580 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PRIC285 peroxisomal proliferator-activated receptor A interacting complex 285".

Dopunska literatura

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Surapureddi S, Yu S, Bu H, et al. (2002). "Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator". Proc. Natl. Acad. Sci. U.S.A. 99 (18): 11836–41. doi:10.1073/pnas.182426699. PMC 129355. PMID 12189208.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Tomaru T, Satoh T, Yoshino S, et al. (2006). "Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma". Endocrinology. 147 (1): 377–88. doi:10.1210/en.2005-0450. PMID 16239304.