PPIP5K2

Difosfoinozitol-pentakisfosfatna kinaza 2 jest protein/enzim koji je kod ljudi kodiran genom PPIP5K2 sa hromosoma 5.^[5]

PPIP5K2
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 3T54, 3T7A, 3T99, 3T9A, 3T9B, 3T9C, 3T9D, 3T9E, 3T9F, 4HN2, 4NZM, 4NZN, 4NZO, 4Q4C, 4Q4D, 5BYA, 5BYB
Identifikatori
Aliasi	PPIP5K2
Vanjski ID-jevi	OMIM: 611648 MGI: 2142810 HomoloGene: 49409 GeneCards: PPIP5K2
Lokacija gena (čovjek) Hrom. Hromosom 5 (čovjek)[1] Bend 5q21.1 Početak 103,120,149 bp[1] Kraj 103,212,799 bp[1]
Lokacija gena (miš) Hrom. Hromosom 1 (miš)[2] Bend 1|1 D Početak 97,706,048 bp[2] Kraj 97,770,411 bp[2]
Ontologija gena Molekularna funkcija • inositol hexakisphosphate 5-kinase activity • aktivnost sa transferazom • inositol hexakisphosphate 1-kinase activity • nucleotide binding • diphosphoinositol-pentakisphosphate kinase activity • inositol-1,3,4,5,6-pentakisphosphate kinase activity • inositol hexakisphosphate 3-kinase activity • kinase activity • inositol hexakisphosphate kinase activity • ATP binding • inositol heptakisphosphate kinase activity • 5-diphosphoinositol pentakisphosphate 3-kinase activity Ćelijska komponenta • citoplazma • citosol Biološki proces • inositol phosphate metabolic process • Fosforilacija • inositol phosphate biosynthetic process • inositol metabolic process Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	23262	227399
Ensembl	ENSG00000145725	ENSMUSG00000040648
UniProt	O43314	Q6ZQB6
RefSeq (mRNK)	NM_001276277 NM_001281471 NM_015216 NM_001345871 NM_001345872 NM_001345873 NM_001345874 NM_001345875 NM_001345876 NM_001345877 NM_001345878	NM_173760
RefSeq (bjelančevina)	NP_001263206 NP_001268400 NP_001332800 NP_001332801 NP_001332802 NP_001332803 NP_001332804 NP_001332805 NP_001332806 NP_001332807 NP_056031	NP_776121 NP_001392387 NP_001392388 NP_001392389 NP_001392390 NP_001392391 NP_001392392 NP_001392393 NP_001392394 NP_001392395 NP_001392396 NP_001392397 NP_001392398 NP_001392399 NP_001392400 NP_001392401 NP_001392402
Lokacija (UCSC)	Chr 5: 103.12 – 103.21 Mb	Chr 1: 97.71 – 97.77 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.243 aminokiseline, а molekulska težina 140.407 Da.^[6]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MSEAPRFFVG		PEDTEINPGN		YRHFFHHADE		DDEEEDDSPP		ERQIVVGICS
MAKKSKSKPM		KEILERISLF		KYITVVVFEE		EVILNEPVEN		WPLCDCLISF
HSKGFPLDKA		VAYAKLRNPF		VINDLNMQYL		IQDRREVYSI		LQAEGILLPR
YAILNRDPNN		PKECNLIEGE		DHVEVNGEVF		QKPFVEKPVS		AEDHNVYIYY
PTSAGGGSQR		LFRKIGSRSS		VYSPESNVRK		TGSYIYEEFM		PTDGTDVKVY
TVGPDYAHAE		ARKSPALDGK		VERDSEGKEV		RYPVILNARE		KLIAWKVCLA
FKQTVCGFDL		LRANGQSYVC		DVNGFSFVKN		SMKYYDDCAK		ILGNIVMREL
APQFHIPWSI		PLEAEDIPIV		PTTSGTMMEL		RCVIAVIRHG		DRTPKQKMKM
EVRHQKFFDL		FEKCDGYKSG		KLKLKKPKQL		QEVLDIARQL		LMELGQNNDS
EIEENKPKLE		QLKTVLEMYG		HFSGINRKVQ		LTYLPHGCPK		TSSEEEDSRR
EEPSLLLVLK		WGGELTPAGR		VQAEELGRAF		RCMYPGGQGD		YAGFPGCGLL
RLHSTYRHDL		KIYASDEGRV		QMTAAAFAKG		LLALEGELTP		ILVQMVKSAN
MNGLLDSDSD		SLSSCQQRVK		ARLHEILQKD		RDFTAEDYEK		LTPSGSISLI
KSMHLIKNPV		KTCDKVYSLI		QSLTSQIRHR		MEDPKSSDIQ		LYHSETLELM
LRRWSKLEKD		FKTKNGRYDI		SKIPDIYDCI		KYDVQHNGSL		KLENTMELYR
LSKALADIVI		PQEYGITKAE		KLEIAKGYCT		PLVRKIRSDL		QRTQDDDTVN
KLHPVYSRGV		LSPERHVRTR		LYFTSESHVH		SLLSILRYGA		LCNESKDEQW
KRAMDYLNVV		NELNYMTQIV		IMLYEDPNKD		LSSEERFHVE		LHFSPGAKGC
EEDKNLPSGY		GYRPASRENE		GRRPFKIDND		DEPHTSKRDE		VDRAVILFKP
MVSEPIHIHR		KSPLPRSRKT		ATNDEESPLS		VSSPEGTGTW		LHYTSGVGTG
RRRRRSGEQI		TSSPVSPKSL		AFTSSIFGSW		QQVVSENANY		LRTPRTLVEQ
KQNPTVGSHC		AGLFSTSVLG		GSSSAPNLQD		YARTHRKKLT		SSGCIDDATR
GSAVKRFSIS		FARHPTNGFE		LYSMVPSICP		LETLHNALSL		KQVDEFLASI
ASPSSDVPRK		TAEISSTALR		SSPIMRKKVS		LNTYTPAKIL		PTPPATLKST
KASSKPATSG		PSSAVVPNTS		SRKKNITSKT		ETHEHKKNTG		KKK

Funkcija

Inozitol-fosfati (IP) i difosfoinozitol-fosfati (PP-IP), poznati i kao inozitol-pirofosfati, djeluju kao molekule ćelijske signalizacije.

HISPPD1 ima aktivnosti IP6 kinaza (EC: 2.7.4.21) i PP-IP5 (također zvane IP7) kinaze (EC: 2.7.4.24) koje proizvode visokoenergetske pirofosfate PP-IP5 i PP2 -IP4 (naziva se i IP8) (Fridy et al., 2007 PubMed 17690096]).

Reference

1. GRCh38: Ensembl release 89: ENSG00000145725 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040648 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Diphosphoinositol pentakisphosphate kinase 2". Pristupljeno 21. 3. 2017.
6. "UniProt, O43314" (jezik: engleski). Pristupljeno 19. 10. 2021.

Dopunska literatura

• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Wang H, Falck JR, Hall TM, Shears SB (2011). "Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding". Nat. Chem. Biol. 8 (1): 111–6. doi:10.1038/nchembio.733. PMC 3923263. PMID 22119861.
• Weaver JD, Wang H, Shears SB (2013). "The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment". Biosci. Rep. 33 (2): e00022. doi:10.1042/BSR20120115. PMC 3564036. PMID 23240582.
• Yong ST, Nguyen HN, Choi JH, Bortner CD, Williams J, Pulloor NK, Krishnan MN, Shears SB (2015). "Identification of a functional nuclear translocation sequence in hPPIP5K2". BMC Cell Biol. 16: 17. doi:10.1186/s12860-015-0063-7. PMC 4472268. PMID 26084399.

Vanjski linkovi

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.