PELI1

PELI1
Identifikatori
Aliasi	PELI1
Vanjski ID-jevi	OMIM: 614797 MGI: 1914495 HomoloGene: 23243 GeneCards: PELI1
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	64,144,420 bp
Lokacija gena (miš)
Hrom.	Hromosom 11 (miš)
Kraj	21,100,323 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0050372 aktivnost sa transferazom ubikvitina; • GO:0001948, GO:0016582 vezivanje za proteine; • ubiquitin-ubiquitin ligase activity; • protein serine/threonine kinase activity; • aktivnost sa transferazom; • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity;
Ćelijska komponenta	• citosol; • jedro;
Biološki proces	• response to dsRNA; • positive regulation of toll-like receptor 3 signaling pathway; • GO:0032737 positive regulation of cytokine production; • protein polyubiquitination; • negative regulation of T cell proliferation; • response to lipopolysaccharide; • positive regulation of B cell proliferation; • protein ubiquitination; • positive regulation of toll-like receptor 4 signaling pathway; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • positive regulation of B cell activation; • negative regulation of NF-kappaB transcription factor activity; • positive regulation of protein ubiquitination; • negative regulation of T cell activation; • protein phosphorylation; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor; • Toll signaling pathway; • protein K48-linked ubiquitination; • interleukin-1-mediated signaling pathway; • proteasome-mediated ubiquitin-dependent protein catabolic process; • negative regulation of necroptotic process; • protein K63-linked ubiquitination; • regulation of Toll signaling pathway;
	Izvori:Amigo / QuickGO
Ortolozi
	57162
	67245
	ENSG00000197329
	ENSMUSG00000020134
	Q96FA3
	Q8C669
	NM_020651
	NM_023324
	NP_065702
	NP_075813
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Prenilcistein-oksidaza 1 jest enzim koji je kod ljudi kodiran genom PCYOX1 sa hromosoma 2.^[5]^[6]^[7]

Kratke činjenice Identifikatori, Aliasi ...

Zatvori

Dužina polipeptidnog lanca je 505 aminokiselina, a molekulska težina 56.640 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGRVVAELVS	SLLGLWLLLC	SCGCPEGAEL	RAPPDKIAII	GAGIGGTSAA
YYLRQKFGKD	VKIDLFEREE	VGGRLATMMV	QGQEYEAGGS	VIHPLNLHMK
RFVKDLGLSA	VQASGGLLGI	YNGETLVFEE	SNWFIINVIK	LVWRYGFQSL
RMHMWVEDVL	DKFMRIYRYQ	SHDYAFSSVE	KLLHALGGDD	FLGMLNRTLL
ETLQKAGFSE	KFLNEMIAPV	MRVNYGQSTD	INAFVGAVSL	SCSDSGLWAV
EGGNKLVCSG	LLQASKSNLI	SGSVMYIEEK	TKTKYTGNPT	KMYEVVYQIG
TETRSDFYDI	VLVATPLNRK	MSNITFLNFD	PPIEEFHQYY	QHIVTTLVKG
ELNTSIFSSR	PIDKFGLNTV	LTTDNSDLFI	NSIGIVPSVR	EKEDPEPSTD
GTYVWKIFSQ	ETLTKAQILK	LFLSYDYAVK	KPWLAYPHYK	PPEKCPSIIL
HDRLYYLNGI	ECAASAMEMS	AIAAHNAALL	AYHRWNGHTD	MIDQDGLYEK
LKTEL

Prenilcistein-oksidaza

[1]
GRCh38: Ensembl release 89: ENSG00000197329 - Ensembl, maj 2017
[2]
GRCm38: Ensembl release 89: ENSMUSG00000020134 - Ensembl, maj 2017
[3]
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
[4]
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
[5]
Tschantz WR, Zhang L, Casey PJ (Jan 2000). "Cloning, expression, and cellular localization of a human prenylcysteine lyase". J Biol Chem. 274 (50): 35802–8. doi:10.1074/jbc.274.50.35802. PMID 10585463.
[6]
Digits JA, Pyun HJ, Coates RM, Casey PJ (Oct 2002). "Stereospecificity and kinetic mechanism of human prenylcysteine lyase, an unusual thioether oxidase". J Biol Chem. 277 (43): 41086–93. doi:10.1074/jbc.M208069200. PMID 12186880.
[7]
"Entrez Gene: PCYOX1 prenylcysteine oxidase 1".
[8]
"UniProt, Q9UHG3" (jezik: engleski). Pristupljeno 14. 11. 2021.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Zhang L, Tschantz WR, Casey PJ (1997). "Isolation and characterization of a prenylcysteine lyase from bovine brain". J. Biol. Chem. 272 (37): 23354–9. doi:10.1074/jbc.272.37.23354. PMID 9287348.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Wouters MM, Neefs JM, Kerchove d'Exaerde A, et al. (2006). "Downregulation of two novel genes in Sl/Sld and W(LacZ)/Wv mouse jejunum". Biochem. Biophys. Res. Commun. 346 (2): 491–500. doi:10.1016/j.bbrc.2006.05.132. PMID 16765319.^{[mrtav link]}

[refGRCh38Ensembl-1] [1]
GRCh38: Ensembl release 89: ENSG00000197329 - Ensembl, maj 2017

[refGRCm38Ensembl-2] [2]
GRCm38: Ensembl release 89: ENSMUSG00000020134 - Ensembl, maj 2017

[3] [3]
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] [4]
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10585463-5] [5]
Tschantz WR, Zhang L, Casey PJ (Jan 2000). "Cloning, expression, and cellular localization of a human prenylcysteine lyase". J Biol Chem. 274 (50): 35802–8. doi:10.1074/jbc.274.50.35802. PMID 10585463.

[pmid12186880-6] [6]
Digits JA, Pyun HJ, Coates RM, Casey PJ (Oct 2002). "Stereospecificity and kinetic mechanism of human prenylcysteine lyase, an unusual thioether oxidase". J Biol Chem. 277 (43): 41086–93. doi:10.1074/jbc.M208069200. PMID 12186880.

[entrez-7] [7]
"Entrez Gene: PCYOX1 prenylcysteine oxidase 1".

[UniProt-8] [8]
"UniProt, Q9UHG3" (jezik: engleski). Pristupljeno 14. 11. 2021.

[5]

[6]

[7]

[1]

[2]

[3]

[4]

[8]

Wikiwand in your browser!

PELI1

Wikiwand in your browser!

Amiokiselininska sekvenca

Također pogledajte

Reference

Dopunska literatura

Vanjski linkovi