NREP

Neuronski protein 3.1 jest protein koji je kod ljudi kodiran genom NREP.^[5][6][7] Visoko je eksprimiran u mozgu.^[8]

NREP
Identifikatori
Aliasi	NREP
Vanjski ID-jevi	OMIM: 607332 MGI: 99444 HomoloGene: 70874 GeneCards: NREP
Lokacija gena (čovjek) Hrom. Hromosom 5 (čovjek)[1] Bend 5q22.1 Početak 111,662,621 bp[1] Kraj 111,997,464 bp[1]
Lokacija gena (miš) Hrom. Hromosom 18 (miš)[2] Bend 18|18 B1 Početak 33,570,072 bp[2] Kraj 33,597,082 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • citoplazma • jedro Biološki proces • regulation of neuron differentiation • axon regeneration • regulation of transforming growth factor beta receptor signaling pathway Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	9315	27528
Ensembl	ENSG00000134986	ENSMUSG00000042834
UniProt	Q16612	Q07475
RefSeq (mRNK)	NM_001142474 NM_001142475 NM_001142476 NM_001142477 NM_001142478 NM_001142479 NM_001142480 NM_001142481 NM_001142482 NM_001142483 NM_004772	NM_001109988 NM_001109989 NM_001267717 NM_053078
RefSeq (bjelančevina)	NP_001135946 NP_001135947 NP_001135948 NP_001135949 NP_001135950 NP_001135951 NP_001135952 NP_001135953 NP_001135954 NP_001135955 NP_004763	NP_001103458 NP_001103459 NP_001254646 NP_444308
Lokacija (UCSC)	Chr 5: 111.66 – 112 Mb	Chr 18: 33.57 – 33.6 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 68 aminokiselina, а molekulska težina 7.909 Da.^[9]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MVYYPELFVW		VSQEPFPNKD		MEGRLPKGRL		PVPKEVNRKK		NDETNAASLT
PLGSSELRSP		RISYLHFF

Reference

1. GRCh38: Ensembl release 89: ENSG00000134986 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042834 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Studler JM, Glowinski J, Lévi-Strauss M (Jun 1993). "An abundant mRNA of the embryonic brain persists at a high level in cerebellum, hippocampus and olfactory bulb during adulthood". The European Journal of Neuroscience. 5 (6): 614–23. doi:10.1111/j.1460-9568.1993.tb00527.x. PMID 8261136. S2CID 35425949.
6. Miura N, Naganuma A (Aug 2000). "Metallothionein mediates gene expression of 3.1 mRNA (PTZ17) related to epileptic seizure". FEBS Letters. 479 (3): 146–8. doi:10.1016/S0014-5793(00)01899-8. PMID 10981724. S2CID 9344664.
7. "Entrez Gene: C5orf13 chromosome 5 open reading frame 13".
8. "Human Gene NREP (ENST00000447165.6) Description and Page Index". genome.ucsc.edu.
9. "UniProt, Q16612" (jezik: engleski). Pristupljeno 13. 10. 2021.

Dopunska literatura

• Taylor GA, Hudson E, Resau JH, Vande Woude GF (Feb 2000). "Regulation of P311 expression by Met-hepatocyte growth factor/scatter factor and the ubiquitin/proteasome system". The Journal of Biological Chemistry. 275 (6): 4215–9. doi:10.1074/jbc.275.6.4215. PMID 10660586.
• Pan D, Zhe X, Jakkaraju S, Taylor GA, Schuger L (Nov 2002). "P311 induces a TGF-beta1-independent, nonfibrogenic myofibroblast phenotype". The Journal of Clinical Investigation. 110 (9): 1349–58. doi:10.1172/JCI15614. PMC 151607. PMID 12417574.
• McDonough WS, Tran NL, Berens ME (Sep 2005). "Regulation of glioma cell migration by serine-phosphorylated P311". Neoplasia. 7 (9): 862–72. doi:10.1593/neo.05190. PMC 1501936. PMID 16229809.
• Zhao L, Leung JK, Yamamoto H, Goswami S, Kheradmand F, Vu TH (Jul 2006). "Identification of P311 as a potential gene regulating alveolar generation". American Journal of Respiratory Cell and Molecular Biology. 35 (1): 48–54. doi:10.1165/rcmb.2005-0475OC. PMC 2658697. PMID 16484684.

Vanjski linkovi

• Lokacija ljudskog genoma NREP i stranica sa detaljima o genu NREP u UCSC Genome Browseru.