IK (gen)

Protein Red jest protein koji je kod ljudi kodiran genom IK sa hromosoma 5.^[5][6]

IK (gen)
Identifikatori
Aliasi	IK
Vanjski ID-jevi	OMIM: 600549 MGI: 1345142 HomoloGene: 36193 GeneCards: IK
Lokacija gena (čovjek) Hrom. Hromosom 5 (čovjek)[1] Bend 5q31.3 Početak 140,647,058 bp[1] Kraj 140,662,480 bp[1]
Lokacija gena (miš) Hrom. Hromosom 18 (miš)[2] Bend 18|18 B2 Početak 36,877,709 bp[2] Kraj 36,890,692 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje identičnih proteina Ćelijska komponenta • nuclear speck • nuclear chromosome • mitotic spindle pole • spindle pole • nukleoplazma • spliceosomal complex • hromosom • citoplazma • citoskelet • jedro • U2-type precatalytic spliceosome Biološki proces • GO:0007067 Mitoza • mitotic spindle assembly checkpoint signaling • protein localization to kinetochore • mRNA processing • Prerada RNK • GO:0022415 viral process • mRNA splicing, via spliceosome Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	3550	24010
Ensembl	ENSG00000113141	ENSMUSG00000024474
UniProt	Q13123 Q95HA6	Q9Z1M8
RefSeq (mRNK)	NM_006083	NM_011879
RefSeq (bjelančevina)	NP_006074 NP_006074.2	NP_036009
Lokacija (UCSC)	Chr 5: 140.65 – 140.66 Mb	Chr 18: 36.88 – 36.89 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 557 aminokiselina, а molekulska težina 65.602 Da.^[7]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MPERDSEPFS		NPLAPDGHDV		DDPHSFHQSK		LTNEDFRKLL		MTPRAAPTSA
PPSKSRHHEM		PREYNEDEDP		AARRRKKKSY		YAKLRQQEIE		RERELAEKYR
DRAKERRDGV		NKDYEETELI		STTANYRAVG		PTAEADKSAA		EKRRQLIQES
KFLGGDMEHT		HLVKGLDFAL		LQKVRAEIAS		KEKEEEELME		KPQKETKKDE
DPENKIEFKT		RLGRNVYRML		FKSKAYERNE		LFLPGRMAYV		VDLDDEYADT
DIPTTLIRSK		ADCPTMEAQT		TLTTNDIVIS		KLTQILSYLR		QGTRNKKLKK
KDKGKLEEKK		PPEADMNIFE		DIGDYVPSTT		KTPRDKERER		YRERERDRER
DRDRDRERER		ERDRERERER		DREREEEKKR		HSYFEKPKVD		DEPMDVDKGP
GSTKELIKSI		NEKFAGSAGW		EGTESLKKPE		DKKQLGDFFG		MSNSYAECYP
ATMDDMAVDS		DEEVDYSKMD		QGNKKGPLGR		WDFDTQEEYS		EYMNNKEALP
KAAFQYGIKM		SEGRKTRRFK		ETNDKAELDR		QWKKISAIIE		KRKKMEADGV
EVKRPKY

Funkcija

Protein kodiran ovim genom identificiran je njegovim RED ponavljanjem, nizom ponovljenih ostataka arginina, glutaminske kiseline i asparaginske kiseline. Protein se nalazi u diskretnim tačkicama unutar jedra, isključujući nukleolus. Njegova funkcija nije poznata. Ovaj gen se mapira na hromosomu 5; međutim, njegov pseudogen može biti i na hromosomu 2.^[6]

Reference

1. GRCh38: Ensembl release 89: ENSG00000113141 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024474 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Krief P, Augery-Bourget Y, Plaisance S, Merck MF, Assier E, Tanchou V, Billard M, Boucheix C, Jasmin C, Azzarone B (Dec 1994). "A new cytokine (IK) down-regulating HLA class II: monoclonal antibodies, cloning and chromosome localization". Oncogene. 9 (12): 3449–56. PMID 7970704.
6. "Entrez Gene: IK IK cytokine, down-regulator of HLA II".
7. "UniProt, Q13123" (jezik: engleski). Pristupljeno 16. 10. 2021.

Dopunska literatura

• Cao LX, Le Bousse-Kerdiles MC, Clay D, et al. (1997). "Implication of a new molecule IK in CD34+ hematopoietic progenitor cell proliferation and differentiation". Blood. 89 (10): 3615–23. doi:10.1182/blood.V89.10.3615. PMID 9160666.
• Assier E, Bouzinba-Segard H, Stolzenberg MC, et al. (1999). "Isolation, sequencing and expression of RED, a novel human gene encoding an acidic-basic dipeptide repeat". Gene. 230 (2): 145–54. doi:10.1016/S0378-1119(99)00066-9. PMID 10216252.
• Willers J, Häffner A, Zepter K, et al. (2001). "The interferon inhibiting cytokine IK is overexpressed in cutaneous T cell lymphoma derived tumor cells that fail to upregulate major histocompatibility complex class II upon interferon-gamma stimulation". J. Invest. Dermatol. 116 (6): 874–9. doi:10.1046/j.1523-1747.2001.01339.x. PMID 11407974.