HRC

Histidinom bogati kalcij-vezujući protein sarkoplazmatskog retikuluma je protein koji je kod ljudi kodiran genom HRC.^[3][4]

HRC
Identifikatori
Aliasi	HRC
Vanjski ID-jevi	OMIM: 142705 HomoloGene: 135866 GeneCards: HRC
Lokacija gena (čovjek) Hrom. Hromosom 19 (čovjek)[1] Bend 19q13.33 Početak 49,151,198 bp[1] Kraj 49,155,396 bp[1]
Ontologija gena Molekularna funkcija • ATPase binding • transmembrane transporter binding • GO:0001948, GO:0016582 vezivanje za proteine • calcium ion binding Ćelijska komponenta • sarcoplasmic reticulum lumen • Sarkoplazmatski retikulum • Z disc • sarcoplasmic reticulum membrane • endoplasmic reticulum lumen Biološki proces • Mišićna kontrakcija • regulation of ryanodine-sensitive calcium-release channel activity • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • positive regulation of relaxation of cardiac muscle • regulation of heart rate • regulation of calcium ion transmembrane transport • positive regulation of heart rate • calcium ion homeostasis • regulation of peptidyl-serine phosphorylation • regulation of heart contraction • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion • regulation of cytosolic calcium ion concentration • positive regulation of heart contraction • regulation of cell communication by electrical coupling involved in cardiac conduction • Posttranslacione modifikacije • negative regulation of cytosolic calcium ion concentration Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	3270	n/a
Ensembl	ENSG00000130528	n/a
UniProt	P23327	n/a
RefSeq (mRNK)	NM_002152	n/a
RefSeq (bjelančevina)	NP_002143	n/a
Lokacija (UCSC)	Chr 19: 49.15 – 49.16 Mb	n/a
PubMed pretraga	[2]	n/a
Wikipodaci
Pogledaj/uredi – čovjek

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MGHHRPWLHA		SVLWAGVASL		LLPPAMTQQL		RGDGLGFRNR		NNSTGVAGLS
EEASAELRHH		LHSPRDHPDE		NKDVSTENGH		HFWSHPDREK		EDEDVSKEYG
HLLPGHRSQD		HKVGDEGVSG		EEVFAEHGGQ		ARGHRGHGSE		DTEDSAEHRH
HLPSHRSHSH		QDEDEDEVVS		SEHHHHILRH		GHRGHDGEDD		EGEEEEEEEE
EEEEASTEYG		HQAHRHRGHG		SEEDEDVSDG		HHHHGPSHRH		QGHEEDDDDD
DDDDDDDDDD		DVSIEYRHQA		HRHQGHGIEE		DEDVSDGHHH		RDPSHRHRSH
EEDDNDDDDV		STEYGHQAHR		HQDHRKEEVE		AVSGEHHHHV		PDHRHQGHRD
EEEDEDVSTE		RWHQGPQHVH		HGLVDEEEEE		EEITVQFGHY		VASHQPRGHK
SDEEDFQDEY		KTEVPHHHHH		RVPREEDEEV		SAELGHQAPS		HRQSHQDEET
GHGQRGSIKE		MSHHPPGHTV		VKDRSHLRKD		DSEEEKEKEE		DPGSHEEDDE
SSEQGEKGTH		HGSRDQEDEE		DEEEGHGLSL		NQEEEEEEDK		EEEEEEEDEE
RREERAEVGA		PLSPDHSEEE		EEEEEGLEED		EPRFTIIPNP		LDRREEAGGA
SSEEESGEDT		GPQDAQEYGN		YQPGSLCGYC		SFCNRCTECE		SCHCDEENMG
EHCDQCQHCQ		FCYLCPLVCE		TVCAPGSYVD		YFSSSLYQAL		ADMLETPEP

Funkcija

Protein koji veže kalcijem bogati histidin je luminalni protein sarkoplazmatskog retikuluma od 165 kD, prepoznatljiv po svojoj sposobnosti da veže lipoprotein male gustoće, sa visokim afinitetom.^[4]

Reference

1. GRCh38: Ensembl release 89: ENSG00000130528 - Ensembl, maj 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Hofmann SL, Topham M, Hsieh CL, Francke U (Apr 1991). "cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7". Genomics. 9 (4): 656–69. doi:10.1016/0888-7543(91)90359-M. PMID 2037293.
4. "Entrez Gene: HRC histidine rich calcium binding protein".

Dopunska literatura

• Anderson NL, Anderson NG (Nov 2002). "The human plasma proteome: history, character, and diagnostic prospects". Molecular & Cellular Proteomics. 1 (11): 845–67. doi:10.1074/mcp.R200007-MCP200. PMID 12488461.
• Hofmann SL, Brown MS, Lee E, Pathak RK, Anderson RG, Goldstein JL (maj 1989). "Purification of a sarcoplasmic reticulum protein that binds Ca2+ and plasma lipoproteins". The Journal of Biological Chemistry. 264 (14): 8260–70. PMID 2498310.
• Ridgeway AG, Petropoulos H, Siu A, Ball JK, Skerjanc IS (Aug 1999). "Cloning, tissue distribution, subcellular localization and overexpression of murine histidine-rich Ca2+ binding protein". FEBS Letters. 456 (3): 399–402. doi:10.1016/S0014-5793(99)00993-X. PMID 10462052. S2CID 19920072.
• Lee HG, Kang H, Kim DH, Park WJ (Oct 2001). "Interaction of HRC (histidine-rich Ca(2+)-binding protein) and triadin in the lumen of sarcoplasmic reticulum". The Journal of Biological Chemistry. 276 (43): 39533–8. doi:10.1074/jbc.M010664200. PMID 11504710.
• Sacchetto R, Damiani E, Turcato F, Nori A, Margreth A (Dec 2001). "Ca(2+)-dependent interaction of triadin with histidine-rich Ca(2+)-binding protein carboxyl-terminal region". Biochemical and Biophysical Research Communications. 289 (5): 1125–34. doi:10.1006/bbrc.2001.6126. PMID 11741309.
• Kim E, Shin DW, Hong CS, Jeong D, Kim DH, Park WJ (Jan 2003). "Increased Ca2+ storage capacity in the sarcoplasmic reticulum by overexpression of HRC (histidine-rich Ca2+ binding protein)". Biochemical and Biophysical Research Communications. 300 (1): 192–6. doi:10.1016/S0006-291X(02)02829-2. PMID 12480542.
• Adkins JN, Varnum SM, Auberry KJ, Moore RJ, Angell NH, Smith RD, Springer DL, Pounds JG (Dec 2002). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Molecular & Cellular Proteomics. 1 (12): 947–55. doi:10.1074/mcp.M200066-MCP200. PMID 12543931.
• Anderson JP, Dodou E, Heidt AB, De Val SJ, Jaehnig EJ, Greene SB, Olson EN, Black BL (maj 2004). "HRC is a direct transcriptional target of MEF2 during cardiac, skeletal, and arterial smooth muscle development in vivo". Molecular and Cellular Biology. 24 (9): 3757–68. doi:10.1128/MCB.24.9.3757-3768.2004. PMC 387749. PMID 15082771.
• Fan GC, Gregory KN, Zhao W, Park WJ, Kranias EG (Oct 2004). "Regulation of myocardial function by histidine-rich, calcium-binding protein". American Journal of Physiology. Heart and Circulatory Physiology. 287 (4): H1705–11. doi:10.1152/ajpheart.01211.2003. PMID 15191886. S2CID 15011211.
• Arvanitis DA, Vafiadaki E, Fan GC, Mitton BA, Gregory KN, Del Monte F, Kontrogianni-Konstantopoulos A, Sanoudou D, Kranias EG (Sep 2007). "Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase". American Journal of Physiology. Heart and Circulatory Physiology. 293 (3): H1581–9. doi:10.1152/ajpheart.00278.2007. PMID 17526652.
• Singh VP, Rubinstein J, Arvanitis DA, Ren X, Gao X, Haghighi K, Gilbert M, Iyer VR, Kim DH, Cho C, Jones K, Lorenz JN, Armstrong CF, Wang HS, Gyorke S, Kranias EG (2013). "Abnormal calcium cycling and cardiac arrhythmias associated with the human Ser96Ala genetic variant of histidine-rich calcium-binding protein". Journal of the American Heart Association. 2 (5): e000460. doi:10.1161/JAHA.113.000460. PMC 3835262. PMID 24125847.