Elongacijski pridruženi faktor 2 jest protein koji je kod ljudi kodiran genom EAF2 sa hromosoma 3.[5][6][7] Član je EAF porodice proteina.
Kratke činjenice Identifikatori, Aliasi ...
EAF2 |
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Identifikatori |
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Aliasi | EAF2 |
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Vanjski ID-jevi | OMIM: 607659 MGI: 2146616 HomoloGene: 10208 GeneCards: EAF2 |
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Ontologija gena |
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Molekularna funkcija | • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 vezivanje za proteine
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Ćelijska komponenta | • nuclear speck • transcription elongation factor complex • super elongation complex • jedro • nukleoplazma
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Biološki proces | • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:0009373 regulation of transcription, DNA-templated • negative regulation of cell growth • negative regulation of epithelial cell proliferation involved in prostate gland development • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription, DNA-templated • GO:0097285 apoptoza • transcription by RNA polymerase II • transcription elongation from RNA polymerase II promoter
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Izvori:Amigo / QuickGO |
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Ortolozi |
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Vrste | Čovjek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNK) | | |
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RefSeq (bjelančevina) | | |
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Lokacija (UCSC) | Chr 3: 121.84 – 121.89 Mb | Chr 16: 36.61 – 36.7 Mb |
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PubMed pretraga | [3] | [4] |
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Wikipodaci |
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Zatvori
Dužina polipeptidnog lanca je 260 aminokiselina, а molekulska težina 28.792 Da.[8]
10 | | 20 | | 30 | | 40 | | 50 |
MNSAAGFSHL | | DRRERVLKLG | | ESFEKQPRCA | | FHTVRYDFKP | | ASIDTSSEGY |
LEVGEGEQVT | | ITLPNIEGST | | PPVTVFKGSK | | KPYLKECILI | | INHDTGECRL |
EKLSSNITVK | | KTRVEGSSKI | | QYRKEQQQQQ | | MWNSARTPNL | | VKHSPSEDKM |
SPASPIDDIE | | RELKAEASLM | | DQMSSCDSSS | | DSKSSSSSSS | | EDSSSDSEDE |
DCKSSTSDTG | | NCVSGHPTMT | | QYRIPDIDAS | | HNRFRDNSGL | | LMNTLRNDLQ |
LSESGSDSDD |
Xiao W, Zhang Q, Jiang F, Pins M, Kozlowski JM, Wang Z (Aug 2003). "Suppression of prostate tumor growth by U19, a novel testosterone-regulated apoptosis inducer". Cancer Res. 63 (15): 4698–704. PMID 12907652.
- Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Saso K, Ito T, Natori S, Sekimizu K (2004). "Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II". J. Biochem. 133 (4): 493–500. doi:10.1093/jb/mvg065. PMID 12761297.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Kong SE, Banks CA, Shilatifard A, et al. (2005). "ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL". Proc. Natl. Acad. Sci. U.S.A. 102 (29): 10094–8. doi:10.1073/pnas.0503017102. PMC 1177379. PMID 16006523.
- Xiao W, Jiang F, Wang Z (2006). "ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation". Prostate. 66 (1): 1–12. doi:10.1002/pros.20309. PMID 16114057. S2CID 32749490.
- Jiang F, Ai J, Xiao W, Wang Z (2007). "FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity". Cancer Lett. 253 (2): 265–72. doi:10.1016/j.canlet.2007.02.003. PMC 1989770. PMID 17395368.