Dihidropirimidinazi-srodni protein 5 jest enzim koji je kod ljudi kodiran genom DPYSL5 sa hromosoma 2.[5][6][7]
Kratke činjenice Dostupne strukture, PDB ...
Zatvori
Dužina polipeptidnog lanca je 564 aminokiseline, a molkekulska iežina 61.421 Da.[8]
10 | | 20 | | 30 | | 40 | | 50 |
MLANSASVRI | | LIKGGKVVND | | DCTHEADVYI | | ENGIIQQVGR | | ELMIPGGAKV |
IDATGKLVIP | | GGIDTSTHFH | | QTFMNATCVD | | DFYHGTKAAL | | VGGTTMIIGH |
VLPDKETSLV | | DAYEKCRGLA | | DPKVCCDYAL | | HVGITWWAPK | | VKAEMETLVR |
EKGVNSFQMF | | MTYKDLYMLR | | DSELYQVLHA | | CKDIGAIARV | | HAENGELVAE |
GAKEALDLGI | | TGPEGIEISR | | PEELEAEATH | | RVITIANRTH | | CPIYLVNVSS |
ISAGDVIAAA | | KMQGKVVLAE | | TTTAHATLTG | | LHYYHQDWSH | | AAAYVTVPPL |
RLDTNTSTYL | | MSLLANDTLN | | IVASDHRPFT | | TKQKAMGKED | | FTKIPHGVSG |
VQDRMSVIWE | | RGVVGGKMDE | | NRFVAVTSSN | | AAKLLNLYPR | | KGRIIPGADA |
DVVVWDPEAT | | KTISASTQVQ | | GGDFNLYENM | | RCHGVPLVTI | | SRGRVVYENG |
VFMCAEGTGK | | FCPLRSFPDT | | VYKKLVQREK | | TLKVRGVDRT | | PYLGDVAVVV |
HPGKKEMGTP | | LADTPTRPVT | | RHGGMRDLHE | | SSFSLSGSQI | | DDHVPKRASA |
RILAPPGGRS | | SGIW |
Vjeruje se da članovi porodice CRMP, kao što je DPYSL5, imaju ulogu u konusu rasta tokom razvoja nervnog sistema (prema OMIM[7])
- Cross SA, Salomao DR, Parisi JE, et al. (2003). "Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgG". Ann. Neurol. 54 (1): 38–50. doi:10.1002/ana.10587. PMID 12838519. S2CID 36493404.
- Fukada M, Watakabe I, Yuasa-Kawada J, et al. (2001). "Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family". J. Biol. Chem. 275 (48): 37957–65. doi:10.1074/jbc.M003277200. PMID 10956643.
- Yu Z, Kryzer TJ, Griesmann GE, et al. (2001). "CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity". Ann. Neurol. 49 (2): 146–54. doi:10.1002/1531-8249(20010201)49:2<146::AID-ANA34>3.0.CO;2-E. PMID 11220734.
- Ricard D, Rogemond V, Charrier E, et al. (2001). "Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin response mediator protein 5 (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a- sensitive oligodendrocytes". J. Neurosci. 21 (18): 7203–14. doi:10.1523/JNEUROSCI.21-18-07203.2001. PMC 6763003. PMID 11549731.
- Mitsui N, Inatome R, Takahashi S, et al. (2002). "Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling". EMBO J. 21 (13): 3274–85. doi:10.1093/emboj/cdf328. PMC 125392. PMID 12093729.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.