CHRNA2

Podjedinica alfa-2 receptora neuronskog acetilholina, znana i kao nAChRα2, je protein koji je kod ljudi kodiran genom CHRNA2.^[5][6] Protein kodiran ovim genom podjedinica je nekih nikotinskih acetilholinskih receptora (nAchR).

CHRNA2
Identifikatori
Aliasi	CHRNA2
Vanjski ID-jevi	OMIM: 118502 MGI: 87886 HomoloGene: 20193 GeneCards: CHRNA2
Lokacija gena (čovjek) Hrom. Hromosom 8 (čovjek)[1] Bend 8p21.2 Početak 27,459,756 bp[1] Kraj 27,479,883 bp[1]
Lokacija gena (miš) Hrom. Hromosom 14 (miš)[2] Bend 14 D1|14 34.36 cM Početak 66,372,488 bp[2] Kraj 66,390,397 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • acetylcholine binding • acetylcholine receptor activity • ion channel activity • extracellular ligand-gated ion channel activity • ligand-gated ion channel activity • acetylcholine-gated cation-selective channel activity • transmembrane signaling receptor activity Ćelijska komponenta • integral component of membrane • acetylcholine-gated channel complex • postsynaptic membrane • membrana • ćelijska membrana • sinapsa • međućelijske veze • cell periphery • integral component of plasma membrane • neuron projection Biološki proces • protein heterooligomerization • response to nicotine • synaptic transmission, cholinergic • ion transport • neuromuscular synaptic transmission • GO:0072468 Transdukcija signala • regulation of postsynaptic membrane potential • excitatory postsynaptic potential • ion transmembrane transport • chemical synaptic transmission • regulation of membrane potential • nervous system process • transmembrane transport Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	1135	110902
Ensembl	ENSG00000120903	ENSMUSG00000022041
UniProt	Q15822	Q91X60
RefSeq (mRNK)	NM_000742 NM_001282455 NM_001347705 NM_001347706 NM_001347707 NM_001347708	NM_144803
RefSeq (bjelančevina)	NP_000733 NP_001269384 NP_001334634 NP_001334635 NP_001334636 NP_001334637	NP_659052
Lokacija (UCSC)	Chr 8: 27.46 – 27.48 Mb	Chr 14: 66.37 – 66.39 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 529 aminokiselina, а molekulska težina 59.765 Da.^[7]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MGPSCPVFLS		FTKLSLWWLL		LTPAGGEEAK		RPPPRAPGDP		LSSPSPTALP
QGGSHTETED		RLFKHLFRGY		NRWARPVPNT		SDVVIVRFGL		SIAQLIDVDE
KNQMMTTNVW		LKQEWSDYKL		RWNPTDFGNI		TSLRVPSEMI		WIPDIVLYNN
ADGEFAVTHM		TKAHLFSTGT		VHWVPPAIYK		SSCSIDVTFF		PFDQQNCKMK
FGSWTYDKAK		IDLEQMEQTV		DLKDYWESGE		WAIVNATGTY		NSKKYDCCAE
IYPDVTYAFV		IRRLPLFYTI		NLIIPCLLIS		CLTVLVFYLP		SDCGEKITLC
ISVLLSLTVF		LLLITEIIPS		TSLVIPLIGE		YLLFTMIFVT		LSIVITVFVL
NVHHRSPSTH		TMPHWVRGAL		LGCVPRWLLM		NRPPPPVELC		HPLRLKLSPS
YHWLESNVDA		EEREVVVEEE		DRWACAGHVA		PSVGTLCSHG		HLHSGASGPK
AEALLQEGEL		LLSPHMQKAL		EGVHYIADHL		RSEDADSSVK		EDWKYVAMVI
DRIFLWLFII		VCFLGTIGLF		LPPFLAGMI

Funkcija

Nokaut ovog mišjeg gena potencira nikotinski modulirana ponašanja.^[8] Upotrebom dvije različite genetički modificirane mišje mutantne linije (Chrna2L9'S/L9'S i Chrna2KO), nalazi su upozorili da α2* nAChR-ovi utiču na hipokampusno ovisno učenje, pamćenje i sinapsnu plastičnost kod adolescentnih miševa.^[9]

Također pogledajte

• Receptor nikotin-acetilholina