Protein 7 vezan za ćelijski ciklus jest protein koji je kod ljudi kodiran genom CDCA7 sa hromosoma 2.[5][6][7]
Kratke činjenice Identifikatori, Aliasi ...
Zatvori
Dužina polipeptidnog lanca je 371 aminokiselina, a molekulska težina 42.573 Da.[8]
10 | | 20 | | 30 | | 40 | | 50 |
MDARRVPQKD | | LRVKKNLKKF | | RYVKLISMET | | SSSSDDSCDS | | FASDNFANTR |
LQSVREGCRT | | RSQCRHSGPL | | RVAMKFPARS | | TRGATNKKAE | | SRQPSENSVT |
DSNSDSEDES | | GMNFLEKRAL | | NIKQNKAMLA | | KLMSELESFP | | GSFRGRHPLP |
GSDSQSRRPR | | RRTFPGVASR | | RNPERRARPL | | TRSRSRILGS | | LDALPMEEEE |
EEDKYMLVRK | | RKTVDGYMNE | | DDLPRSRRSR | | SSVTLPHIIR | | PVEEITEEEL |
ENVCSNSREK | | IYNRSLGSTC | | HQCRQKTIDT | | KTNCRNPDCW | | GVRGQFCGPC |
LRNRYGEEVR | | DALLDPNWHC | | PPCRGICNCS | | FCRQRDGRCA | | TGVLVYLAKY |
HGFGNVHAYL | | KSLKQEFEMQ | | A |
Ovaj gen je identificiran kao c-Myc gen koji reagira i ponaša se kao direktan c-Myc ciljni gen. Utvrđeno je da prekomjerna ekspresija ovog gena pojačava transformaciju limfoblastoidnih ćelija i nadopunjuje transformacijski defektni Myc kutijski mutant II, sugerirajući njegovu uključenost u c-Myc posredovanu transformaciju ćelija. Prijavljene su dvije alternativno prerađene varijante transkripta koje kodiraju različite izoforme.[7]
Prescott JE, Osthus RC, Lee LA, Lewis BC, Shim H, Barrett JF, Guo Q, Hawkins AL, Griffin CA, Dang CV (Dec 2001). "A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation". J Biol Chem. 276 (51): 48276–84. doi:10.1074/jbc.M107357200. PMID 11598121.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
- Osthus RC, Karim B, Prescott JE, et al. (2005). "The Myc target gene JPO1/CDCA7 is frequently overexpressed in human tumors and has limited transforming activity in vivo". Cancer Res. 65 (13): 5620–7. doi:10.1158/0008-5472.CAN-05-0536. PMC 1224734. PMID 15994934.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Goto Y, Hayashi R, Muramatsu T, et al. (2006). "JPO1/CDCA7, a novel transcription factor E2F1-induced protein, possesses intrinsic transcriptional regulator activity". Biochim. Biophys. Acta. 1759 (1–2): 60–8. doi:10.1016/j.bbaexp.2006.02.004. PMID 16580749.