Karbonil reduktaza [NADPH] 3 jest enzim koji je kod ljudi kodiran genom CBR3 sa hromosoma 21.[5][6][7]
Kratke činjenice Dostupne strukture, PDB ...
Zatvori
Dužina polipeptidnog lanca je 277 aminokiselina, a molekulska težina 30.850 Da.
10 | | 20 | | 30 | | 40 | | 50 |
MSSCSRVALV | | TGANRGIGLA | | IARELCRQFS | | GDVVLTARDV | | ARGQAAVQQL |
QAEGLSPRFH | | QLDIDDLQSI | | RALRDFLRKE | | YGGLNVLVNN | | AAVAFKSDDP |
MPFDIKAEMT | | LKTNFFATRN | | MCNELLPIMK | | PHGRVVNISS | | LQCLRAFENC |
SEDLQERFHS | | ETLTEGDLVD | | LMKKFVEDTK | | NEVHEREGWP | | NSPYGVSKLG |
VTVLSRILAR | | RLDEKRKADR | | ILVNACCPGP | | VKTDMDGKDS | | IRTVEEGAET |
PVYLALLPPD | | ATEPQGQLVH | | DKVVQNW |
Karbonil reduktaza 3 katalizira redukciju velikog broja biološki i farmakološki aktivnih karbonil spojeva u njihove odgovarajuće alkohole. Enzim je klasifikovan kao monomerna NADPH-zavisna oksidoreduktaza. CBR3 sadrži tri egzona koji se protežu na 11,2 kilobaza i usko je povezan sa drugim genom karbonil reduktaze - CBR1.[7]
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- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Dahmane N, Ghezala GA, Gosset P, et al. (1998). "Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome". Genomics. 48 (1): 12–23. doi:10.1006/geno.1997.5146. PMID 9503011.
- Ismail E, Al-Mulla F, Tsuchida S, et al. (2000). "Carbonyl reductase: a novel metastasis-modulating function". Cancer Res. 60 (5): 1173–6. PMID 10728668.
- Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
- Umemoto M, Yokoyama Y, Sato S, et al. (2001). "Carbonyl reductase as a significant predictor of survival and lymph node metastasis in epithelial ovarian cancer". Br. J. Cancer. 85 (7): 1032–6. doi:10.1038/sj.bjc.6692034. PMC 2375107. PMID 11592776.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Lakhman SS, Ghosh D, Blanco JG (2005). "Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3)". Drug Metab. Dispos. 33 (2): 254–7. doi:10.1124/dmd.104.002006. PMID 15537833. S2CID 18027092.