ZNF784

Protein 784 cinkovog prsta je protein koji je kod ljudi kodiran genom ZNF784.^[5]

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MAAARPEAQS		RSSPTPESRS		QEPLDLVLVP		DDCRPGTPPS		DLIEIQVVKV
TDTTLVPEPP		EPGSFHCALC		PAAFRLVSEL		LFHEHGHLAG		AEGGGQGGDP
SRCHVCGHSC		PGPASLRAHY		SLHTGERPYR		CALCPRAFKA		LAPLLRHQHR
HGVEPGTSRR		PPDTAAVAEQ		RPGVAPERAE		VVMAAAAAGA		AVGKPFACRF
CAKPFRRSSD		MRDHERVHTG		ERPYHCGICG		KGFTQSSVLS		GHARIHTGER
PFRCTLCDRT		FNNSSNFRKH		QRTHFHGPGP		GLGDSGGQLG		SSAAEGSGSG
CGVGDPAEEG		RGETAKVKVE		ADQ

ZNF784
Identifikatori
Aliasi	ZNF784
Vanjski ID-jevi	MGI: 3606042 HomoloGene: 52408 GeneCards: ZNF784
Lokacija gena (čovjek) Hrom. Hromosom 19 (čovjek)[1] Bend 19q13.42 Početak 55,620,741 bp[1] Kraj 55,624,566 bp[1]
Lokacija gena (miš) Hrom. Hromosom 7 (miš)[2] Bend 7|7 A1 Početak 5,037,438 bp[2] Kraj 5,041,445 bp[2]
Ontologija gena Molekularna funkcija • vezivanje sa DNK • vezivanje iona metala • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sequence-specific DNA binding Ćelijska komponenta • jedro • nukleoplazma Biološki proces • GO:0009373 regulation of transcription, DNA-templated • hematopoietic progenitor cell differentiation • transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • GO:0045996 negative regulation of transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	147808	654801
Ensembl	ENSG00000179922	ENSMUSG00000043290
UniProt	Q8NCA9	Q8BI69
RefSeq (mRNK)	NM_203374	NM_001039532
RefSeq (bjelančevina)	NP_976308	NP_001034621
Lokacija (UCSC)	Chr 19: 55.62 – 55.62 Mb	Chr 7: 5.04 – 5.04 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Interakcije

Pokazalo se da proteini cinkovog prsta ulaze u interakciju s nukleinskim kiselinama i imaju različite funkcije. Domen cinkovog prsta je konzervirani motiv aminokiselinske sekvence koji sadrži po dva posebno postavljena cisteina i histidina, koji su uključeni u koordinaciju cinka. Proteini povezani sa Kruppelom čine jednu porodicu proteina cinkovih prstiju.^[5]

Reference

1. GRCh38: Ensembl release 89: ENSG00000179922 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043290 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Zinc finger protein 784". Pristupljeno 2. 2. 2016.

Vanjski linkovi