Endotelni protein cinkovog prsta induciran faktorom tumorske nekroze alfa je protein koji je kod ljudi kodiran genom ZNF71.[3][4]
Kratke činjenice Identifikatori, Aliasi ...
| ZNF71 |
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| Identifikatori |
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| Aliasi | ZNF71 |
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| Vanjski ID-jevi | OMIM: 194545 HomoloGene: 81885 GeneCards: ZNF71 |
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| Ontologija gena |
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| Molekularna funkcija | • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• vezivanje sa DNK
• vezivanje iona metala
• nucleic acid binding
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
• sequence-specific DNA binding
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| Ćelijska komponenta | • jedro
• nukleoplazma
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| Biološki proces | • GO:0009373 regulation of transcription, DNA-templated
• transcription, DNA-templated
• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
• GO:0045996 negative regulation of transcription, DNA-templated
• GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
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| Izvori:Amigo / QuickGO |
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| Ortolozi |
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| Vrste | Čovjek | Miš |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNK) | | |
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| RefSeq (bjelančevina) | | |
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| Lokacija (UCSC) | Chr 19: 56.6 – 56.63 Mb | n/a |
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| PubMed pretraga | [2] | n/a |
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| Wikipodaci |
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Zatvori
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| MKELDPKNDI | | SEDKLSVVGE | | ATGGPTRNGA | | RGPGSEGVWE | | PGSWPERPRG |
| DAGAEWEPLG | | IPQGNKLLGG | | SVPACHELKA | | FANQGCVLVP | | PRLDDPTEKG |
| ACPPVRRGKN | | FSSTSDLSKP | | PMPCEEKKTY | | DCSECGKAFS | | RSSSLIKHQR |
| IHTGEKPFEC | | DTCGKHFIER | | SSLTIHQRVH | | TGEKPYACGD | | CGKAFSQRMN |
| LTVHQRTHTG | | EKPYVCDVCG | | KAFRKTSSLT | | QHERIHTGEK | | PYACGDCGKA |
| FSQNMHLIVH | | QRTHTGEKPY | | VCPECGRAFS | | QNMHLTEHQR | | THTGEKPYAC |
| KECGKAFNKS | | SSLTLHQRNH | | TGEKPYVCGE | | CGKAFSQSSY | | LIQHQRFHIG |
| VKPFECSECG | | KAFSKNSSLT | | QHQRIHTGEK | | PYECYICKKH | | FTGRSSLIVH |
| QIVHTGEKPY | | VCGECGKAFS | | QSAYLIEHQR | | IHTGEKPYRC | | GQCGKSFIKN |
| SSLTVHQRIH | | TGEKPYRCGE | | CGKTFSRNTN | | LTRHLRIHT |
Pokazalo se da proteini cinkovog prsta ulaze u interakciju s nukleinskim kiselinama i imaju različite funkcije. Domen cinkovog prsta je konzervirani motiv aminokiselinske sekvence koji sadrži po dva posebno postavljena cisteina i histidina, koji su uključeni u koordinaciju cinka. Proteini povezani sa Kruppelom čine jednu porodicu proteina cinkovih prstiju.[4]
Aubry M, Marineau C, Zhang FR, Zahed L, Figlewicz D, Delattre O, Thomas G, de Jong PJ, Julien JP, Rouleau GA (Aug 1992). "Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2)". Genomics. 13 (3): 641–8. doi:10.1016/0888-7543(92)90135-F. PMID 1639391.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Mataki C, Murakami T, Umetani M, et al. (2001). "A novel zinc finger protein mRNA in human umbilical vein endothelial cells is profoundly induced by tumor necrosis factor alpha". J. Atheroscler. Thromb. 7 (2): 97–103. doi:10.5551/jat1994.7.97. PMID 11426589.
- Bray P, Lichter P, Thiesen HJ, et al. (1991). "Characterization and mapping of human genes encoding zinc finger proteins". Proc. Natl. Acad. Sci. U.S.A. 88 (21): 9563–7. doi:10.1073/pnas.88.21.9563. PMC 52758. PMID 1946370.
- Lichter P, Bray P, Ried T, et al. (1992). "Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes". Genomics. 13 (4): 999–1007. doi:10.1016/0888-7543(92)90013-I. PMID 1505991.
