Protein 649 cinkovog prsta je protein koji je kod ljudi kodiran genom ZNF649. Nalazi se na hromosomu 19 i ima pet egzona.[3][4]
- Aminokiselinska sekvenca
- Simboli
| 10 | | 20 | | 30 | | 40 | | 50 |
|---|
| MTKAQESLTL | | EDVAVDFTWE | | EWQFLSPAQK | | DLYRDVMLEN | | YSNLVSVGYQ |
| AGKPDALTKL | | EQGEPLWTLE | | DEIHSPAHPE | | IEKADDHLQQ | | PLQNQKILKR |
| TGQRYEHGRT | | LKSYLGLTNQ | | SRRYNRKEPA | | EFNGDGAFLH | | DNHEQMPTEI |
| EFPESRKPIS | | TKSQFLKHQQ | | THNIEKAHEC | | TDCGKAFLKK | | SQLTEHKRIH |
| TGKKPHVCSL | | CGKAFYKKYR | | LTEHERAHRG | | EKPHGCSLCG | | KAFYKRYRLT |
| EHERAHKGEK | | PYGCSECGKA | | FPRKSELTEH | | QRIHTGIKPH | | QCSECGRAFS |
| RKSLLVVHQR | | THTGEKPHTC | | SECGKGFIQK | | GNLNIHQRTH | | TGEKPYGCID |
| CGKAFSQKSC | | LVAHQRYHTG | | KTPFVCPECG | | QPCSQKSGLI | | RHQKIHSGEK |
| PYKCSDCGKA | | FLTKTMLIVH | | HRTHTGERPY | | GCDECEKAYF | | YMSCLVKHKR |
| IHSREKRGDS | | VKVENPSTAS | | HSLSPSEHVQ | | GKSPVNMVTV | | AMVAGQCEFA |
| HILHS |
Kratke činjenice Identifikatori, Aliasi ...
| ZNF649 |
|---|
|
| Identifikatori |
|---|
| Aliasi | ZNF649 |
|---|
| Vanjski ID-jevi | OMIM: 611903 HomoloGene: 56964 GeneCards: ZNF649 |
|---|
|
|
| Ontologija gena |
|---|
| Molekularna funkcija | • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• vezivanje sa DNK
• GO:0001948, GO:0016582 vezivanje za proteine
• vezivanje iona metala
• nucleic acid binding
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
|
|---|
| Ćelijska komponenta | • intracellular anatomical structure
• jedro
• Vanćelijsko
• nukleoplazma
|
|---|
| Biološki proces | • GO:0009373 regulation of transcription, DNA-templated
• GO:1901227 negative regulation of transcription by RNA polymerase II
• transcription, DNA-templated
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
|
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| Izvori:Amigo / QuickGO |
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| Ortolozi |
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| Vrste | Čovjek | Miš |
|---|
| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNK) | | |
|---|
| RefSeq (bjelančevina) | | |
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| Lokacija (UCSC) | Chr 19: 51.89 – 51.91 Mb | n/a |
|---|
| PubMed pretraga | [2] | n/a |
|---|
| Wikipodaci |
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Zatvori
Pokazalo se da proteini cinkovog prsta ulaze u interakciju s nukleinskim kiselinama i imaju različite funkcije. Domen cinkovog prsta je konzervirani motiv aminokiselinske sekvence koji sadrži po dva posebno postavljena cisteina i histidina, koji su uključeni u koordinaciju cinka. Proteini povezani sa Kruppelom čine jednu porodicu proteina cinkovih prstiju.[4]
Yang H, Yuan W, Wang Y, Zhu C, Liu B, Wang Y, Yang D, Li Y, Wang C, Wu X, Liu M (Jul 2005). "ZNF649, a novel Kruppel type zinc-finger protein, functions as a transcriptional suppressor". Biochem Biophys Res Commun. 333 (1): 206–15. doi:10.1016/j.bbrc.2005.05.101. PMID 15950191.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
