TWSG1

Uvijeni homolog 1 proteina gastrulacije je protein koji je kod ljudi kodiran genom TWSG1.^[5][6]

TWSG1
Identifikatori
Aliasi	TWSG1
Vanjski ID-jevi	OMIM: 605049 MGI: 2137520 HomoloGene: 10774 GeneCards: TWSG1
Lokacija gena (čovjek) Hrom. Hromosom 18 (čovjek)[1] Bend 18p11.22 Početak 9,334,767 bp[1] Kraj 9,402,420 bp[1]
Lokacija gena (miš) Hrom. Hromosom 17 (miš)[2] Bend 17 E1.1|17 35.26 cM Početak 66,228,967 bp[2] Kraj 66,258,221 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine • transforming growth factor beta binding Ćelijska komponenta • extracellular region • Vanćelijsko Biološki proces • negative regulation of BMP signaling pathway • multicellular organism development • mesoderm formation • Ćelijska diferencijacija • forebrain development • camera-type eye development • salivary gland morphogenesis • BMP signaling pathway • ossification • negative regulation of osteoblast differentiation • tissue development • positive regulation of BMP signaling pathway • GO:0032697 negative regulation of cytokine production • transforming growth factor beta receptor signaling pathway • positive regulation of pathway-restricted SMAD protein phosphorylation • negative regulation of CD4-positive, alpha-beta T cell activation • negative regulation of CD4-positive, alpha-beta T cell proliferation • Hematopoeza Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	57045	65960
Ensembl	ENSG00000128791	ENSMUSG00000024098
UniProt	Q9GZX9	Q9EP52
RefSeq (mRNK)	NM_020648	NM_023053
RefSeq (bjelančevina)	NP_065699	NP_075540
Lokacija (UCSC)	Chr 18: 9.33 – 9.4 Mb	Chr 17: 66.23 – 66.26 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Dužina polipeptidnog lanca je 223 aminokiseline, sa molekulskom težinom 25.017 kD.^[7].

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MKLHYVAVLT		LAILMFLTWL		PESLSCNKAL		CASDVSKCLI		QELCQCRPGE
GNCSCCKECM		LCLGALWDEC		CDCVGMCNPR		NYSDTPPTSK		STVEELHEPI
PSLFRALTEG		DTQLNWNIVS		FPVAEELSHH		ENLVSFLETV		NQPHHQNVSV
PSNNVHAPYS		SDKEHMCTVV		YFDDCMSIHQ		CKISCESMGA		SKYRWFHNAC
CECIGPECID		YGSKTVKCMN		CMF

Reference

1. GRCh38: Ensembl release 89: ENSG00000128791 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024098 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Scott IC, Blitz IL, Pappano WN, Maas SA, Cho KW, Greenspan DS (Mar 2001). "Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling". Nature. 410 (6827): 475–8. doi:10.1038/35068572. PMID 11260715. S2CID 4392365.
6. "Entrez Gene: TWSG1 twisted gastrulation homolog 1 (Drosophila)".
7. "UniProt, Q9GZX9". Pristupljeno 12. 9. 2017.

Dopunska literatura

• Oelgeschläger M, Larraín J, Geissert D, De Robertis EM (2000). "The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling". Nature. 405 (6788): 757–63. doi:10.1038/35015500. PMC 2292104. PMID 10866189.
• Graf D, Timmons PM, Hitchins M, et al. (2001). "Evolutionary conservation, developmental expression, and genomic mapping of mammalian Twisted gastrulation". Mamm. Genome. 12 (7): 554–60. doi:10.1007/s0033501-0005-x. PMID 11420619. S2CID 36371559.
• Graf D, Nethisinghe S, Palmer DB, et al. (2002). "The developmentally regulated expression of Twisted gastrulation reveals a role for bone morphogenetic proteins in the control of T cell development". J. Exp. Med. 196 (2): 163–71. doi:10.1084/jem.20020276. PMC 2193926. PMID 12119341.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zakin L, De Robertis EM (2004). "Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain development". Development. 131 (2): 413–24. doi:10.1242/dev.00946. PMID 14681194.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Moreno M, Muñoz R, Aroca F, et al. (2005). "Biglycan is a new extracellular component of the Chordin-BMP4 signaling pathway". EMBO J. 24 (7): 1397–405. doi:10.1038/sj.emboj.7600615. PMC 1142540. PMID 15775969.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Tzachanis D, Li L, Lafuente EM, et al. (2007). "Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes". Blood. 109 (7): 2944–52. doi:10.1182/blood-2006-03-006510. PMC 1852213. PMID 17164348.