Transmembranski protein 59 jest protein koji je kod ljudi kodiran genom TMEM59 sa hromosoma 1.[5][6]
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Zatvori
Dužina polipeptidnog lanca je 323 aminokiseline, a molekulska težina 36.223 Da.[7]
10 | | 20 | | 30 | | 40 | | 50 |
MAAPKGSLWV | | RTQLGLPPLL | | LLTMALAGGS | | GTASAEAFDS | | VLGDTASCHR |
ACQLTYPLHT | | YPKEEELYAC | | QRGCRLFSIC | | QFVDDGIDLN | | RTKLECESAC |
TEAYSQSDEQ | | YACHLGCQNQ | | LPFAELRQEQ | | LMSLMPKMHL | | LFPLTLVRSF |
WSDMMDSAQS | | FITSSWTFYL | | QADDGKIVIF | | QSKPEIQYAP | | HLEQEPTNLR |
ESSLSKMSYL | | QMRNSQAHRN | | FLEDGESDGF | | LRCLSLNSGW | | ILTTTLVLSV |
MVLLWICCAT | | VATAVEQYVP | | SEKLSIYGDL | | EFMNEQKLNR | | YPASSLVVVR |
SKTEDHEEAG | | PLPTKVNLAH | | SEI |
TMEM59 je protein vezan za membranu koji je lokaliziran na Golgijev aparat.[8] Precizna funkcija TMEM59 nije poznata, ali je pokazano da ekspresija TMEM59 proteina inhibira Golgi glikozilaciju prekursora amiloidnog proteina (APP) i blokira cijepanje APP pomoću α- i β-amiloidno prekursorske proteinske sekrecije i stoga inhibira stvaranje beta-amiloidnog peptida koji formira amiloidne plakove kod Alzheimerove bolesti.[8] Štaviše, TMEM59 je pokazalo se da potencira wnt signalizaciju promicanjem formiranja signalosomskog wnt receptora. Utvrđeno je da transmembranske interakcije između TMEM59 i wnt receptora Frizzled pokreću multimerizaciju receptora, što dovodi do poboljšane potencije i efikasnosti wnt-signalizacije.[9]
Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (juli 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160. Gerlach JP, Jordens I, Tauriello DV, van 't Land-Kuper I, Bugter JM, Noordstra I, van der Kooij J, Low TY, Pimentel-Muiños FX, Xanthakis D, Fenderico N, Rabouille C, Heck AJ, Egan DA, Maurice MM (april 2018). "TMEM59 potentiates Wnt signaling by promoting signalosome formation". Proceedings of the National Academy of Sciences of the United States of America. 115 (17): E3996–E4005. doi:10.1073/pnas.1721321115. PMC 5924918. PMID 29632210.
- Maruyama K, Sugano S (januar 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (oktobar 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (oktobar 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
- Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (oktobar 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.