TMEM123

Porimin ili transmembranski protein 123 je protein koji je kod ljudi kodiran genom TMEM123.^[5][6]

TMEM123
Identifikatori
Aliasi	TMEM123
Vanjski ID-jevi	OMIM: 606356 MGI: 1919179 HomoloGene: 14177 GeneCards: TMEM123
Lokacija gena (čovjek) Hrom. Hromosom 11 (čovjek)[1] Bend 11q22.2 Početak 102,396,332 bp[1] Kraj 102,470,384 bp[1]
Lokacija gena (miš) Hrom. Hromosom 9 (miš)[2] Bend 9|9 A1 Početak 7,764,042 bp[2] Kraj 7,794,334 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine • signaling receptor activity Ćelijska komponenta • integral component of membrane • membrana • external side of plasma membrane • GO:0016023 citoplazmatska vezikula Biološki proces • oncosis • GO:0072468 Transdukcija signala Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	114908	71929
Ensembl	ENSG00000152558	ENSMUSG00000050912
UniProt	Q8N131	Q91Z22
RefSeq (mRNK)	NM_052932	NM_133739
RefSeq (bjelančevina)	NP_443164	NP_598500
Lokacija (UCSC)	Chr 11: 102.4 – 102.47 Mb	Chr 9: 7.76 – 7.79 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Ovaj gen kodira visoko glikozilirani transmembranski protein s visokim sadržajem ostataka treonina i serina u svom vanćelijskom domenu, slično široko definiranoj kategoriji proteina zvanoj mucini.

Izloženost nekih tipova ćelija antiporminskih (ozljeda membrane koja izaziva receptore proonkoze) antitijela, umrežava ovaj protein na ćelijskoj površini i izaziva tip ćelijske smrti koji se naziva onkoza.

Onkoza se razlikuje od apoptoze i karakterizira je gubitak integriteta ćelijske membrane bez fragmentacije DNK. Predloženo je da ovaj genski proizvod funkcionira kao receptor na ćelijskoj površini koji posreduje u ćelijskoj smrti.^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 208 aminokiselina, а molekulska težina 21.531 Da.^[7]

10		20		30		40		50
MGLGARGAWA		ALLLGTLQVL		ALLGAAHESA		AMAASANIEN		SGLPHNSSAN
STETLQHVPS		DHTNETSNST		VKPPTSVASD		SSNTTVTTMK		PTAASNTTTP
GMVSTNMTST		TLKSTPKTTS		VSQNTSQIST		STMTVTHNSS		VTSAASSVTI
TTTMHSEAKK		GSKFDTGSFV		GGIVLTLGVL		SILYIGCKMY		YSRRGIRYRT
IDEHDAII

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

Reference

1. GRCh38: Ensembl release 89: ENSG00000152558 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050912 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ma F, Zhang C, Prasad KV, Freeman GJ, Schlossman SF (Aug 2001). "Molecular cloning of Porimin, a novel cell surface receptor mediating oncotic cell death". Proc Natl Acad Sci U S A. 98 (17): 9778–83. doi:10.1073/pnas.171322898. PMC 55529. PMID 11481458.
6. "Entrez Gene: TMEM123 transmembrane protein 123".
7. "UniProt, Q8N131". Pristupljeno 28. 8. 2021.

Dopunska literatura

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• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Zhang C, Xu Y, Gu J, Schlossman SF (1998). "A cell surface receptor defined by a mAb mediates a unique type of cell death similar to oncosis". Proc. Natl. Acad. Sci. U.S.A. 95 (11): 6290–5. doi:10.1073/pnas.95.11.6290. PMC 27661. PMID 9600958.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bonkobara M, Das A, Takao J, et al. (2003). "Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes". Br. J. Dermatol. 148 (4): 654–64. doi:10.1046/j.1365-2133.2003.05244.x. PMID 12752121. S2CID 21635573.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.