TMEM109

Transmembranski protein 109 je protein koji je kod ljudi kodiran genom TMEM109. ^[5]

Aminokiselinska sekvenca

TMEM109
Identifikatori
Aliasi	TMEM109
Vanjski ID-jevi	MGI: 1915789 HomoloGene: 11458 GeneCards: TMEM109
Lokacija gena (čovjek) Hrom. Hromosom 11 (čovjek)[1] Bend 11q12.2 Početak 60,914,158 bp[1] Kraj 60,923,443 bp[1]
Lokacija gena (miš) Hrom. Hromosom 19 (miš)[2] Bend 19|19 A Početak 10,848,024 bp[2] Kraj 10,859,365 bp[2]
Ontologija gena Molekularna funkcija • voltage-gated ion channel activity • molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • sarcoplasmic reticulum membrane • Egzosom • endoplasmic reticulum membrane • jedro • membrana • Sarkoplazmatski retikulum • nuclear outer membrane • integral component of membrane • Endoplazmatski retikulum Biološki proces • ion transport • negative regulation of cell death • cellular response to gamma radiation • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • regulation of ion transmembrane transport • GO:0015915 transport • ion transmembrane transport Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	79073	68539
Ensembl	ENSG00000110108	ENSMUSG00000034659
UniProt	Q9BVC6	Q3UBX0
RefSeq (mRNK)	NM_024092	NM_134142
RefSeq (bjelančevina)	NP_076997	NP_598903
Lokacija (UCSC)	Chr 11: 60.91 – 60.92 Mb	Chr 19: 10.85 – 10.86 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Dužina polipeptidnog lanca je 243 aminokiseline, а molekulska težina 26.210 Da.^[6].

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MAASSISSPW		GKHVFKAILM		VLVALILLHS		ALAQSRRDFA		PPGQQKREAP
VDVLTQIGRS		VRGTLDAWIG		PETMHLVSES		SSQVLWAISS		AISVAFFALS
GIAAQLLNAL		GLAGDYLAQG		LKLSPGQVQT		FLLWGAGALV		VYWLLSLLLG
LVLALLGRIL		WGLKLVIFLA		GFVALMRSVP		DPSTRALLLL		ALLILYALLS
RLTGSRASGA		QLEAKVRGLE		RQVEELRWRQ		RRAAKGARSV		EEE

Ovaj protein tvori kationski ionski kanal u membrani endoplazmatskog retikuluma, skupljajući šest identičnih podjedinica.^[7]

Reference

1. GRCh38: Ensembl release 89: ENSG00000110108 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034659 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Transmembrane protein 109". Pristupljeno 2. 7. 2016.
6. "UniProt, Q9BVC6". Pristupljeno 28. 8. 2021.
7. Venturi, Elisa; Mio, Kazuhiro; Nishi, Miyuki; Ogura, Toshihiko; Moriya, Toshio; Pitt, Samantha J.; Okuda, Kazutaka; Kakizawa, Sho; Sitsapesan, Rebecca; Sato, Chikara; Takeshima, Hiroshi (2011). "Mitsugumin 23 Forms a Massive Bowl-Shaped Assembly and Cation-Conducting Channel". Biochemistry. 50 (13): 2623–2632. doi:10.1021/bi1019447. ISSN 0006-2960.

Dopunska literatura

• Yamazaki T, Sasaki N, Nishi M, Takeshima H (2010). "Facilitation of DNA damage-induced apoptosis by endoplasmic reticulum protein mitsugumin23". Biochem. Biophys. Res. Commun. 392 (2): 196–200. doi:10.1016/j.bbrc.2010.01.013. PMID 20060811.