TMED1

Transmembranski emp24 domen-sadržavajući protein 1 je protein koji je kod ljudi kodiran genom TMED1.^[5][6][7]

TMED1
Identifikatori
Aliasi	TMED1
Vanjski ID-jevi	OMIM: 605395 MGI: 106201 HomoloGene: 21360 GeneCards: TMED1
Lokacija gena (čovjek) Hrom. Hromosom 19 (čovjek)[1] Bend 19p13.2 Početak 10,832,067 bp[1] Kraj 10,836,318 bp[1]
Lokacija gena (miš) Hrom. Hromosom 9 (miš)[2] Bend 9|9 A3 Početak 21,418,849 bp[2] Kraj 21,421,548 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • signaling receptor binding • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • integral component of membrane • Golđijev aparat • endoplasmic reticulum-Golgi intermediate compartment membrane • endoplasmic reticulum-Golgi intermediate compartment • ćelijska membrana • endoplasmic reticulum membrane • membrana • Endoplazmatski retikulum • COPII-coated ER to Golgi transport vesicle Biološki proces • protein transport • GO:0072468 Transdukcija signala • cell-cell signaling • intracellular protein transport • endoplasmic reticulum to Golgi vesicle-mediated transport • Golgi organization Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	11018	17083
Ensembl	ENSG00000099203	ENSMUSG00000032180
UniProt	Q13445	Q3V009
RefSeq (mRNK)	NM_006858	NM_010744 NM_001324510
RefSeq (bjelančevina)	NP_006849	NP_001311439 NP_034874
Lokacija (UCSC)	Chr 19: 10.83 – 10.84 Mb	Chr 9: 21.42 – 21.42 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Protein kodiran ovim genom identificiran je njegovom interakcijom s receptorima poput interleukina 1 (IL1RL1). Ovaj protein nema nikakve sličnosti s drugim ligandima interleukina 1. Funkcionalni značaj njegove interakcije s IL1RL1 nije poznat.^[7]

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MMAAGAALAL		ALWLLMPPVE		VGGAGPPPIQ		DGEFTFLLPA		GRKQCFYQSA
PANASLETEY		QVIGGAGLDV		DFTLESPQGV		LLVSESRKAD		GVHTVEPTEA
GDYKLCFDNS		FSTISEKLVF		FELIFDSLQD		DEEVEGWAEA		VEPEEMLDVK
MEDIKESIET		MRTRLERSIQ		MLTLLRAFEA		RDRNLQEGNL		ERVNFWSAVN
VAVLLLVAVL		QVCTLKRFFQ		DKRPVPT

Reference

1. GRCh38: Ensembl release 89: ENSG00000099203 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032180 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chan WL, Pejnovic N, Lee CA, Al-Ali NA (Jul 2001). "Human IL-18 receptor and ST2L are stable and selective markers for the respective type 1 and type 2 circulating lymphocytes". J Immunol. 167 (3): 1238–44. doi:10.4049/jimmunol.167.3.1238. PMID 11466339.
6. Gayle MA, Slack JL, Bonnert TP, Renshaw BR, Sonoda G, Taguchi T, Testa JR, Dower SK, Sims JE (Jun 1996). "Cloning of a putative ligand for the T1/ST2 receptor". J Biol Chem. 271 (10): 5784–9. doi:10.1074/jbc.271.10.5784. PMID 8621446.
7. "Entrez Gene: TMED1 transmembrane emp24 protein transport domain containing 1".

Dopunska literatura

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.