Protein 4 sa THAP domenom jest protein koji je kod ljudi kodiran genom THAP4 sa hromosoma 2.[5][6][7]
Kratke činjenice Dostupne strukture, PDB ...
THAP4 |
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Identifikatori |
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Aliasi | THAP4 |
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Vanjski ID-jevi | OMIM: 612533 MGI: 1914276 HomoloGene: 12075 GeneCards: THAP4 |
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Ontologija gena |
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Molekularna funkcija | • vezivanje iona metala • vezivanje sa DNK • nucleic acid binding • heme binding • protein homodimerization activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
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Ćelijska komponenta | • ćelijska komponenta
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Biološki proces | • GO:0022610 biološki proces • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
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Izvori:Amigo / QuickGO |
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Ortolozi |
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Vrste | Čovjek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNK) | | |
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RefSeq (bjelančevina) | | |
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Lokacija (UCSC) | Chr 2: 241.58 – 241.64 Mb | Chr 1: 93.63 – 93.68 Mb |
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PubMed pretraga | [3] | [4] |
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Wikipodaci |
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Zatvori
Dužina polipeptidnog lanca je 577 aminokiselina, a molekulska težina 62.890 Da.[8]
10 | | 20 | | 30 | | 40 | | 50 |
MVICCAAVNC | | SNRQGKGEKR | | AVSFHRFPLK | | DSKRLIQWLK | | AVQRDNWTPT |
KYSFLCSEHF | | TKDSFSKRLE | | DQHRLLKPTA | | VPSIFHLTEK | | KRGAGGHGRT |
RRKDASKATG | | GVRGHSSAAT | | SRGAAGWSPS | | SSGNPMAKPE | | SRRLKQAALQ |
GEATPRAAQE | | AASQEQAQQA | | LERTPGDGLA | | TMVAGSQGKA | | EASATDAGDE |
SATSSIEGGV | | TDKSGISMDD | | FTPPGSGACK | | FIGSLHSYSF | | SSKHTRERPS |
VPREPIDRKR | | LKKDVEPSCS | | GSSLGPDKGL | | AQSPPSSSLT | | ATPQKPSQSP |
SAPPADVTPK | | PATEAVQSEH | | SDASPMSINE | | VILSASGACK | | LIDSLHSYCF |
SSRQNKSQVC | | CLREQVEKKN | | GELKSLRQRV | | SRSDSQVRKL | | QEKLDELRRV |
SVPYPSSLLS | | PSREPPKMNP | | VVEPLSWMLG | | TWLSDPPGAG | | TYPTLQPFQY |
LEEVHISHVG | | QPMLNFSFNS | | FHPDTRKPMH | | RECGFIRLKP | | DTNKVAFVSA |
QNTGVVEVEE | | GEVNGQELCI | | ASHSIARISF | | AKEPHVEQIT | | RKFRLNSEGK |
LEQTVSMATT | | TQPMTQHLHV | | TYKKVTP |
Roussigne M, Kossida S, Lavigne AC, Clouaire T, Ecochard V, Glories A, Amalric F, Girard JP (Feb 2003). "The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase". Trends Biochem Sci. 28 (2): 66–9. doi:10.1016/S0968-0004(02)00013-0. PMID 12575992.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
- Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.