TESPA1

Timocitno eksprimirani pozitivno selektirano pridruženi protein 1 je protein koji je kod ljudi kodiran genom TESPA1.^[4]

TESPA1
Identifikatori
Aliasi	TESPA1
Vanjski ID-jevi	OMIM: 615664 MGI: 1914846 HomoloGene: 106645 GeneCards: TESPA1
Lokacija gena (miš) Hrom. Hromosom 10 (miš)[1] Bend 10|10 D3 Početak 130,158,739 bp[1] Kraj 130,199,980 bp[1]
Ontologija gena Molekularna funkcija • signaling receptor binding Ćelijska komponenta • COP9 signalosome • endoplasmic reticulum membrane • Endoplazmatski retikulum • membrana • citoplazma Biološki proces • COP9 signalosome assembly • positive regulation of T cell differentiation in thymus • positive regulation of T cell receptor signaling pathway Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	9840	67596
Ensembl	ENSG00000135426	ENSMUSG00000034833
UniProt	A2RU30 E9PIT9	Q3U132
RefSeq (mRNK)	NM_001098815 NM_001136030 NM_001261844 NM_014796	NM_183264
RefSeq (bjelančevina)	NP_001092285 NP_001129502 NP_001248773 NP_055611 NP_001338077 NP_001338078 NP_001338079 NP_001338080 NP_001338081 NP_001338082 NP_001338083 NP_001338084	NP_899087
Lokacija (UCSC)	n/a	Chr 10: 130.16 – 130.2 Mb
PubMed pretraga	[2]	[3]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 521 aminokiselina, a molekulska težina 59 213 Da.^[5]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MEASVLSPTS		WEKRRAWLRQ		SRNWQTQVLE		EEAAAALQDV		PDPEPSSLDD
VFQEGNPINK		IEDWLQDCGY		SEEGFSEEAG		QFIYNGFCSH		GTSFEDDLTL
GAEATLLAAN		GKLFSRSFLE		TARPCQLLDL		GCSLASSSMT		GGTNKTSSSI
SEILDKVQED		AEDVLFSLGF		GQEDHKDTSR		IPARFFTTPS		QAKGIDFQLF
LKSQVRRIEM		EDPCLMLASR		FKQVQTLAVT		ADAFFCLYSY		VSKTPVQKFT
PSHMFWNCNH		PTDVPSIRIL		SREPEPQSPR		DRLRKAISKM		CLYTCPRDRP
PPPHNTPKRN		SLDQVVLEVM		DKVKEEKQFL		QQDSDLGQFS		QEDPVPPAEG
KKLPTSPYPC		VFCCEEETQQ		RMSTVLAPSQ		TLDSNPKVPC		CTHSLPIEDP
QWSTDPAQIR		RELCSLPATN		TETHPAKDET		FWKRKSRARK		SLFQKNLMGR
KVKSLDLSIT		QQKWKQSVDR		PELRRSLSQQ		PQDTFDLEEV		QSNSEEEQSQ
SRWPSRPRHP		HHHQTFAGKD		S

Reference

1. GRCm38: Ensembl release 89: ENSMUSG00000034833 - Ensembl, maj 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: Thymocyte expressed, positive selection associated 1".
5. "UniProt, A2RU30". Pristupljeno 14. 8. 2021.

Dopunska literatura

• Fujimoto T, Matsuzaki H, Tanaka M, Shirasawa S (april 2013). "Tespa1 protein is phosphorylated in response to store-operated calcium entry". Biochemical and Biophysical Research Communications. 434 (1): 162–5. doi:10.1016/j.bbrc.2013.02.128. PMID 23541577.
• Matsuzaki H, Fujimoto T, Tanaka M, Shirasawa S (april 2013). "Tespa1 is a novel component of mitochondria-associated endoplasmic reticulum membranes and affects mitochondrial calcium flux". Biochemical and Biophysical Research Communications. 433 (3): 322–6. doi:10.1016/j.bbrc.2013.02.099. PMID 23501103.