TBRG1

TBRG1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2WZO
Identifikatori
Aliasi	TBRG1
Vanjski ID-jevi	OMIM: 610614 MGI: 1100877 HomoloGene: 18102 GeneCards: TBRG1
Lokacija gena (čovjek)
Hrom.	Hromosom 11 (čovjek)
Kraj	124,635,926 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	37,568,608 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• jedro;
Biološki proces	• Replikacija DNK; • ćelijski ciklus; • protein stabilization; • negative regulation of cell population proliferation; • protein localization to nucleoplasm;
	Izvori:Amigo / QuickGO
Ortolozi
	84897
	21376
	ENSG00000154144
	ENSMUSG00000011114
	Q3YBR2
	Q3UB74
	NM_032811
	NM_025289
	NP_116200
	NP_079565
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Beta regulator 1 transformirajućeg faktora rasta je protein koji je kod ljudi kodiran genom TBRG1.^[5]^[6]^[7]

Kratke činjenice Dostupne strukture, PDB ...

Zatvori

Dužina polipeptidnog lanca je 411 aminokiselina, а molekulska težina 44.946 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSLLDGLASS	PRAPLQSSKA	RMKKLPKKSQ	NEKYRLKYLR	LRKAAKATVF
ENAAICDEIA	RLEEKFLKAK	EERRYLLKKL	LQLQALTEGE	VQAAAPSHSS
SLPLTYGVAS	SVGTIQGAGP	ISGPSTGAEE	PFGKKTKKEK	KEKGKENNKL
EVLKKTCKKK	KMAGGARKLV	QPIALDPSGR	PVFPIGLGGL	TVYSLGEIIT
DRPGFHDESA	IYPVGYCSTR	IYASMKCPDQ	KCLYTCQIKD	GGVQPQFEIV
PEDDPQNAIV	SSSADACHAE	LLRTISTTMG	KLMPNLLPAG	ADFFGFSHPA
IHNLIQSCPG	ARKCINYQWV	KFDVCKPGDG	QLPEGLPEND	AAMSFEAFQR
QIFDEDQNDP	LLPGSLDLPE	LQPAAFVSSY	QPMYLTHEPL	VDTHLQHLKS
PSQGSPIQSS	D

[1]
GRCh38: Ensembl release 89: ENSG00000154144 - Ensembl, maj 2017
[2]
GRCm38: Ensembl release 89: ENSMUSG00000011114 - Ensembl, maj 2017
[3]
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
[4]
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
[5]
Babalola GO, Schultz RM (Oct 1995). "Modulation of gene expression in the preimplantation mouse embryo by TGF-alpha and TGF-beta". Mol Reprod Dev. 41 (2): 133–9. doi:10.1002/mrd.1080410203. PMID 7654366. S2CID 84997218.
[6]
Tompkins VS, Hagen J, Frazier AA, Lushnikova T, Fitzgerald MP, di Tommaso A, Ladeveze V, Domann FE, Eischen CM, Quelle DE (Jan 2007). "A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability". J Biol Chem. 282 (2): 1322–33. doi:10.1074/jbc.M609612200. PMID 17110379.
[7]
"Entrez Gene: TBRG1 transforming growth factor beta regulator 1".
[8]
"UniProt, Q3YBR2". Pristupljeno 27. 8. 2021.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Tompkins V, Hagen J, Zediak VP, Quelle DE (2006). "Identification of novel ARF binding proteins by two-hybrid screening". Cell Cycle. 5 (6): 641–6. doi:10.4161/cc.5.6.2560. PMID 16582619.

[refGRCh38Ensembl-1] [1]
GRCh38: Ensembl release 89: ENSG00000154144 - Ensembl, maj 2017

[refGRCm38Ensembl-2] [2]
GRCm38: Ensembl release 89: ENSMUSG00000011114 - Ensembl, maj 2017

[3] [3]
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] [4]
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7654366-5] [5]
Babalola GO, Schultz RM (Oct 1995). "Modulation of gene expression in the preimplantation mouse embryo by TGF-alpha and TGF-beta". Mol Reprod Dev. 41 (2): 133–9. doi:10.1002/mrd.1080410203. PMID 7654366. S2CID 84997218.

[pmid17110379-6] [6]
Tompkins VS, Hagen J, Frazier AA, Lushnikova T, Fitzgerald MP, di Tommaso A, Ladeveze V, Domann FE, Eischen CM, Quelle DE (Jan 2007). "A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability". J Biol Chem. 282 (2): 1322–33. doi:10.1074/jbc.M609612200. PMID 17110379.

[entrez-7] [7]
"Entrez Gene: TBRG1 transforming growth factor beta regulator 1".

[UniProt-8] [8]
"UniProt, Q3YBR2". Pristupljeno 27. 8. 2021.

[5]

[6]

[7]

[1]

[2]

[3]

[4]

[8]

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TBRG1

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Aminokiselinska sekvenca

Reference

Dopunska literatura