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STK35L1

STK35L1

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STK35L1
FunkcijeAminokiselinska sekvencaReferenceDopunsdka literatura

STK35L1 je protein koji je kod ljudi kodiran genom humans is encoded by the STK35 (serin/treonin-kinaza 35).[5] Član je porodice NKF4 (Nova kinazna porodica 4) Ser/Thr kinaza (STK) i kod ljudi svrstan u grupu "ostali" Kinases, Kinomes and Evolution, at Kinase.Com.

Kratke činjenice Identifikatori, Aliasi ...
STK35L1
Identifikatori
AliasiSTK35
Vanjski ID-jeviOMIM: 609370 MGI: 1914583 HomoloGene: 15441 GeneCards: STK35
Lokacija gena (čovjek)
Hromosom 20 (čovjek)
Hrom.Hromosom 20 (čovjek)[1]
Hromosom 20 (čovjek)
Genomska lokacija za STK35L1
Genomska lokacija za STK35L1
Bend20p13Početak2,101,827 bp[1]
Kraj2,177,038 bp[1]
Lokacija gena (miš)
Hromosom 2 (miš)
Hrom.Hromosom 2 (miš)[2]
Hromosom 2 (miš)
Genomska lokacija za STK35L1
Genomska lokacija za STK35L1
Bend2|2 F1Početak129,642,437 bp[2]
Kraj129,674,207 bp[2]
Ontologija gena
Molekularna funkcija• aktivnost sa transferazom
• nucleotide binding
• protein kinase activity
• protein serine/threonine kinase activity
• ATP binding
• kinase activity
Ćelijska komponenta• citoplazma
• Jedarce
• jedro
• nuclear body
Biološki proces• protein phosphorylation
• Fosforilacija
• GO:0007126 Mejoza
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

140901

67333

Ensembl

ENSG00000125834

ENSMUSG00000037885

UniProt

Q8TDR2

Q80ZW0

RefSeq (mRNK)

NM_080836

NM_001038635
NM_183262

RefSeq (bjelančevina)

NP_543026

NP_001033724
NP_899085

Lokacija (UCSC)Chr 20: 2.1 – 2.18 MbChr 2: 129.64 – 129.67 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš
Zatvori

Prije toga, STK35L1 je imenovan kao Clik1 (CLP36 interaktivna kinaza 1) na osnovu studije koja je pokazala povezanost STK35 sa CLP36, nakon prekomjerne ekspresije oba proteina u osteosarkomskim ćelijama.[6][7] Gen Clik1 kojeg su opisali Vallenius et al. kodira protein od 501 aminokiselina. Kasnije su Goyal et al. otkrili da kodirajuća sekvenca gena STK35 nije potpuna. Novootkrivena sekvenca gena STK35 kodira protein od 534 aminokiseline sa N-terminalnim izduženjem od 133 aminokiseline. Označen je kao STK35L1.

STK35L1 se pretežno nalazi u jedrui i jedarcetu. Jedarni aktin identificiran je kao novi vezujući partner STK35L1.[8] Međutim, može stupiti u interakciju s PDLIM1 / CLP-36 u citoplazmi i lokalizirati se u vlakna aktinskog stresa. STK35L1 regulira ekspresiju CDKN2A i inhibira prelazak G1- u S-fazu. Osiromašenjem STK35L1 siRNK oštećenim endotelom, migracija ćelija STK35L1 može djelovati kao centralna kinaza koja povezuje ćelijski ciklus i migraciju endotelnih ćelija.

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

1020304050
MGHQESPLARAPAGGAAYVKRLCKGLSWREHVESHGSLGAQASPASAAAA
EGSATRRARAATSRAARSRRQPGPGADHPQAGAPGGKRAARKWRCAGQVT
IQGPAPPRPRAGRRDEAGGARAAPLLLPPPPAAMETGKDGARRGTQSPER
KRRSPVPRAPSTKLRPAAAARAMDPVAAEAPGEAFLARRRPEGGGGSARP
RYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAEFWA
LTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGER
ILGYAEEPCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAF
LHKNHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQ
DNKNVNVNKYWLSSACGSDFYMAPEVWEGHYTAKADIFALGIIIWAMIER
ITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQKRRTSMSE
GIKQLLKDMLAANPQDRPDAFELETRMDQVTCAA
  1. [1]
    GRCh38: Ensembl release 89: ENSG00000125834 - Ensembl, maj 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000037885 - Ensembl, maj 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "Entrez Gene: Serine/threonine kinase 35". Pristupljeno 18. 2. 2012.
  6. [6]
    Vallenius T, Mäkelä TP (maj 2002). "Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein". Journal of Cell Science. 115 (Pt 10): 2067–73. PMID 11973348.
  7. [7]
    Goyal P, Behring A, Kumar A, Siess W (16. 9. 2009). "Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates". PLOS ONE. 4 (9): e6981. doi:10.1371/journal.pone.0006981. PMC 2737284. PMID 19756140.
  8. [8]
    Goyal P, Behring A, Kumar A, Siess W (20. 1. 2011). "STK35L1 associates with nuclear actin and regulates cell cycle and migration of endothelial cells". PLOS ONE. 6 (1): e16249. doi:10.1371/journal.pone.0016249. PMC 3024402. PMID 21283756.
  • Vallenius T, Mäkelä TP (maj 2002). "Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein". Journal of Cell Science. 115 (Pt 10): 2067–73. PMID 11973348.
  • Goyal P, Behring A, Kumar A, Siess W (2009). Randau L (ured.). "Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates". PLOS ONE. 4 (9): e6981. doi:10.1371/journal.pone.0006981. PMC 2737284. PMID 19756140.
  • Goyal P, Behring A, Kumar A, Siess W (2011). Parise G (ured.). "STK35L1 associates with nuclear actin and regulates cell cycle and migration of endothelial cells". PLOS ONE. 6 (1): e16249. doi:10.1371/journal.pone.0016249. PMC 3024402. PMID 21283756.
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Funkcije

Aminokiselinska sekvenca

Reference

Dopunsdka literatura