Sfingomijelin-fosfodiesteraza 4 jest enzim koji je kod ljudi kodiran genom SMPD4 sa hromosoma 2.[5][6]
Kratke činjenice Identifikatori, Aliasi ...
Zatvori
Dužina polipeptidnog lanca je 827 aminokiselina, a molekulska težina 93.352 Da.[7]
10 | | 20 | | 30 | | 40 | | 50 |
MAFPHLQQPS | | FLLASLKADS | | INKPFAQQCQ | | DLVKVIEDFP | | AKELHTIFPW |
LVESIFGSLD | | GVLVGWNLRC | | LQGRVNPVEY | | SIVMEFLDPG | | GPMMKLVYKL |
QAEDYKFDFP | | VSYLPGPVKA | | SIQECILPDS | | PLYHNKVQFT | | PTGGLGLNLA |
LNPFEYYIFF | | FALSLITQKP | | LPVSLHVRTS | | DCAYFILVDR | | YLSWFLPTEG |
SVPPPLSSSP | | GGTSPSPPPR | | TPAIPFASYG | | LHHTSLLKRH | | ISHQTSVNAD |
PASHEIWRSE | | TLLQVFVEMW | | LHHYSLEMYQ | | KMQSPHAKLE | | VLHYRLSVSS |
ALYSPAQPSL | | QALHAYQESF | | TPTEEHVLVV | | RLLLKHLHAF | | ANSLKPEQAS |
PSAHSHATSP | | LEEFKRAAVP | | RFVQQKLYLF | | LQHCFGHWPL | | DASFRAVLEM |
WLSYLQPWRY | | APDKQAPGSD | | SQPRCVSEKW | | APFVQENLLM | | YTKLFVGFLN |
RALRTDLVSP | | KHALMVFRVA | | KVFAQPNLAE | | MIQKGEQLFL | | EPELVIPHRQ |
HRLFTAPTFT | | GSFLSPWPPA | | VTDASFKVKS | | HVYSLEGQDC | | KYTPMFGPEA |
RTLVLRLAQL | | ITQAKHTAKS | | ISDQCAESPA | | GHSFLSWLGF | | SSMDTNGSYT |
ANDLDEMGQD | | SVRKTDEYLE | | KALEYLRQIF | | RLSEAQLRQF | | TLALGTTQDE |
NGKKQLPDCI | | VGEDGLILTP | | LGRYQIINGL | | RRFEIEYQGD | | PELQPIRSYE |
IASLVRTLFR | | LSSAINHRFA | | GQMAALCSRD | | DFLGSFCRYH | | LTEPGLASRH |
LLSPVGRRQV | | AGHTRGPRLS | | LRFLGSYRTL | | VSLLLAFFVA | | SLFCVGPLPC |
TLLLTLGYVL | | YASAMTLLTE | | RGKLHQP |
U proučavanju funkcije gena SMPD4 korišteni su modelni organizmi. Uslovna linij nokaut-miševa pod nazivom Smpd4tm2b(KOMP)Wtsi generirana je na Institutu Welcome Trust Sanger.[8] Muške i ženske životinje su podvrgnute standardizovanom fenotipskom pregledu[9] za određivanje efekata delecija.[10][11][12][13]
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- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
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