Scm-liki protein 1 sa četiri domena mbt jest protein koji je kod ljudi kodiran genom SFMBT1 sa hromosoma 3.[5]
Kratke činjenice Identifikatori, Aliasi ...
SFMBT1 |
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Identifikatori |
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Aliasi | SFMBT1 |
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Vanjski ID-jevi | OMIM: 607319 MGI: 1859609 HomoloGene: 9472 GeneCards: SFMBT1 |
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Ontologija gena |
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Molekularna funkcija | • GO:0001948, GO:0016582 vezivanje za proteine • GO:0001106 transcription corepressor activity • GO:0031493 histone binding
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Ćelijska komponenta | • jedro • nukleoplazma
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Biološki proces | • negative regulation of muscle organ development • Ćelijska diferencijacija • GO:0045996 negative regulation of transcription, DNA-templated • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • Spermatogeneza • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization
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Izvori:Amigo / QuickGO |
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Ortolozi |
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Vrste | Čovjek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNK) | | |
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RefSeq (bjelančevina) | | |
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Lokacija (UCSC) | Chr 3: 52.9 – 53.05 Mb | Chr 14: 30.44 – 30.54 Mb |
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PubMed pretraga | [3] | [4] |
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Wikipodaci |
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Zatvori
Dužina polipeptidnog lanca je 866 aminokiselina, а molekulska težina 98.141 Da.[6]
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MNGEQQLDAD | | AGSGMEEVEL | | SWEDYLEETG | | STAVPYGSFK | | HVDTRLQNGF |
APGMKLEVAV | | RTDPETYWVA | | TVITTCEQLL | | LLRYDGYGED | | RRADFWCDIR |
KADLYPIGWC | | EQNKKTLEAP | | EGIRDKVSDW | | DEFLRQTLIG | | ACSPPVPLLE |
GLRNGRNPLD | | LIAPGSRLEC | | QAFQDSLSTW | | IVTVVENIGG | | RLKLRYEGLE |
SSDNYEHWLY | | YLDPFLHHVG | | WAAQQGYELQ | | PPSAIRHLKN | | EAEWQEILAK |
VKEEEEEPLP | | SYLFKDKQVI | | GIHTFSVNMK | | LEAVDPWSPF | | GISPATVVKV |
FDEKYFLVEM | | DDLRPENHAR | | RSFVCHADSP | | GIFPVQWSLK | | NGLHISPPPG |
YPSQDFDWAD | | YLKQCGAEAA | | PQRCFPPLIS | | EHEFKENMKL | | EAVNPILPEE |
VCVATITAVR | | GSYLWLQLEG | | SKKPIPECIV | | SVESMDIFPL | | GWCETNGHPL |
STPRRARVYK | | QRKIAVVQPE | | KQVPSSRTVH | | EGLRNQELNS | | TESVMINGKY |
CCPKIYFNHR | | CFSGPYLNKG | | RIAELPQCVG | | PGNCVLVLRE | | VLTLLINAAY |
KPSRVLRELQ | | LDKDSVWHGC | | GEVLKAKYKG | | KSYRATVEIV | | KTADRVTEFC |
RQTCIKLECC | | PNLFGPRMVL | | DKCSENCSVL | | TKTKYTHYYG | | KKKNKRIGRP |
PGGHSNLACA | | LKKASKRRKR | | RKNVFVHKKK | | RSSASVDNTP | | AGSPQGSGGE |
DEDDPDEGDD | | DSLSEGSTSE | | QQDELQEESE | | MSEKKSCSSS | | PTQSEISTSL |
PPDRQRRKRE | | LRTFSFSDDE | | NKPPSPKEIR | | IEVAERLHLD | | SNPLKWSVAD |
VVRFIRSTDC | | APLARIFLDQ | | EIDGQALLLL | | TLPTVQECMD | | LKLGPAIKLC |
HHIERIKFAF | | YEQFAN |
Ovaj gen ima veliku sličnost sa genom Scm Drosophila (spolni češalj na srednjoj nozi). Kodira protein koji sadrži četiri ponavljajuća domena malignog tumoa mozga (mbt) i može biti uključen u prepoznavanje antigena (prema RefSeq, juni 2012).
- Zhang, J.; Bonasio, R.; Strino, F.; Kluger, Y.; Holloway, J. K.; Modzelewski, A. J.; Cohen, P. E.; Reinberg, D. (2013). "SFMBT1 functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors". Genes & Development. 27 (7): 749–766. doi:10.1101/gad.210963.112. PMC 3639416. PMID 23592795.
- Köttgen, A.; Albrecht, E.; Teumer, A.; Vitart, V.; Krumsiek, J.; Hundertmark, C.; Pistis, G.; Ruggiero, D.; O'Seaghdha, C. M.; Haller, T.; Yang, Q.; Tanaka, T.; Johnson, A. D.; Kutalik, Z. N.; Smith, A. V.; Shi, J.; Struchalin, M.; Middelberg, R. P. S.; Brown, M. J.; Gaffo, A. L.; Pirastu, N.; Li, G.; Hayward, C.; Zemunik, T.; Huffman, J.; Yengo, L.; Zhao, J. H.; Demirkan, A.; Feitosa, M. F.; et al. (2012). "Genome-wide association analyses identify 18 new loci associated with serum urate concentrations". Nature Genetics. 45 (2): 145–154. doi:10.1038/ng.2500. PMC 3663712. PMID 23263486.
- Kato, T.; Sato, H.; Emi, M.; Seino, T.; Arawaka, S.; Iseki, C.; Takahashi, Y.; Wada, M.; Kawanami, T. (2011). "Segmental copy number loss of SFMBT1 gene in elderly individuals with ventriculomegaly: A community-based study". Internal Medicine (Tokyo, Japan). 50 (4): 297–303. doi:10.2169/internalmedicine.50.4505. PMID 21325761.
- Lin, S.; Shen, H.; Li, J. -L.; Tang, S.; Gu, Y.; Chen, Z.; Hu, C.; Rice, J. C.; Lu, J.; Wu, L. (2013). "Proteomic and Functional Analyses Reveal the Role of Chromatin Reader SFMBT1 in Regulating Epigenetic Silencing and the Myogenic Gene Program". Journal of Biological Chemistry. 288 (9): 6238–6247. doi:10.1074/jbc.M112.429605. PMC 3585059. PMID 23349461.
- Wu, S.; Trievel, R. C.; Rice, J. C. (2007). "Human SFMBT is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3". FEBS Letters. 581 (17): 3289–3296. doi:10.1016/j.febslet.2007.06.025. PMC 2045647. PMID 17599839.
- Yang, H. C.; Liang, Y. J.; Chen, J. W.; Chiang, K. M.; Chung, C. M.; Ho, H. Y.; Ting, C. T.; Lin, T. H.; Sheu, S. H.; Tsai, W. C.; Chen, J. H.; Leu, H. B.; Yin, W. H.; Chiu, T. Y.; Chern, C. I.; Lin, S. J.; Tomlinson, B.; Guo, Y.; Sham, P. C.; Cherny, S. S.; Lam, T. H.; Thomas, G. N.; Pan, W. H. (2012). Mariño-Ramírez, Leonardo (ured.). "Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as Hypertension Susceptibility Genes in Han Chinese with a Genome-Wide Gene-Based Association Study". PLOS ONE. 7 (3): e32907. Bibcode:2012PLoSO...732907Y. doi:10.1371/journal.pone.0032907. PMC 3315540. PMID 22479346.
- Morel, S.; Lévy, F.; Burlet-Schiltz, O.; Brasseur, F.; Probst-Kepper, M.; Peitrequin, A. L.; Monsarrat, B.; Van Velthoven, R.; Cerottini, J. C.; Boon, T.; Gairin, J. E.; Van Den Eynde, B. J. (2000). "Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells". Immunity. 12 (1): 107–117. doi:10.1016/S1074-7613(00)80163-6. PMID 10661410.
Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.