RRS1

Homolog regulacijskog proteina ribosomske biogeneze je protein koji je kod ljudi kodiran genom RRS1.^[5][6][7]

RRS1
Identifikatori
Aliasi	RRS1
Vanjski ID-jevi	OMIM: 618311 MGI: 1929721 HomoloGene: 41014 GeneCards: RRS1
Lokacija gena (čovjek) Hrom. Hromosom 8 (čovjek)[1] Bend 8q13.1 Početak 66,429,014 bp[1] Kraj 66,430,733 bp[1]
Lokacija gena (miš) Hrom. Hromosom 1 (miš)[2] Bend 1 A2|1 2.08 cM Početak 9,615,633 bp[2] Kraj 9,617,680 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje sa RNK • 5S rRNA binding Ćelijska komponenta • kondenzovani nuklearni hromosom • Jedarce • jedro • Endoplazmatski retikulum • preribosome, large subunit precursor • fibrillar center Biološki proces • ribosomal large subunit export from nucleus • mitotic metaphase plate congression • ribosome biogenesis • hematopoietic progenitor cell differentiation • endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • ribosomal large subunit assembly • ribosomal large subunit biogenesis • protein localization to nucleolus • regulation of signal transduction by p53 class mediator Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	23212	59014
Ensembl	ENSG00000179041	ENSMUSG00000061024
UniProt	Q15050	Q9CYH6
RefSeq (mRNK)	NM_015169	NM_021511
RefSeq (bjelančevina)	NP_055984	NP_067486
Lokacija (UCSC)	Chr 8: 66.43 – 66.43 Mb	Chr 1: 9.62 – 9.62 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 365 aminokiselina, а molekulska težina 41.193 Da.^[8]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MEGQSVEELL		AKAEQDEAEK		LQRITVHKEL		ELQFDLGNLL		ASDRNPPTGL
RCAGPTPEAE		LQALARDNTQ		LLINQLWQLP		TERVEEAIVA		RLPEPTTRLP
REKPLPRPRP		LTRWQQFARL		KGIRPKKKTN		LVWDEVSGQW		RRRWGYQRAR
DDTKEWLIEV		PGNADPLEDQ		FAKRIQAKKE		RVAKNELNRL		RNLARAHKMQ
LPSAAGLHPT		GHQSKEELGR		AMQVAKVSTA		SVGRFQERLP		KEKVPRGSGK
KRKFQPLFGD		FAAEKKNQLE		LLRVMNSKKP		QLDVTRATNK		QMREEDQEEA
AKRRKMSQKG		KRKGGRQGPG		GKRKGGPPSQ		GGKRKGGLGG		KMNSGPPGLG
GKRKGGQRPG		GKRRK

Reference

1. GRCh38: Ensembl release 89: ENSG00000179041 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000061024 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
6. Tsuno A, Miyoshi K, Tsujii R, Miyakawa T, Mizuta K (Mar 2000). "RRS1, a Conserved Essential Gene, Encodes a Novel Regulatory Protein Required for Ribosome Biogenesis in Saccharomyces cerevisiae". Mol Cell Biol. 20 (6): 2066–74. doi:10.1128/MCB.20.6.2066-2074.2000. PMC 110823. PMID 10688653.
7. "Entrez Gene: RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)".
8. "UniProt, Q15050" (jezik: engleski). Pristupljeno 21. 9. 2021.

Dopunska literatura

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.