Piwi-likim genom utišavanja RNK-posredovani protein 4 je protein koji je kod ljudi kodirtan genom PIWIL4.[5]
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Dužina polipeptidnog lanca je 852 aminokiseline, a molekulska težina 96.589 Da.[6]
10 | | 20 | | 30 | | 40 | | 50 |
MSGRARVKAR | | GIARSPSATE | | VGRIQASPLP | | RSVDLSNNEA | | SSSNGFLGTS |
RISTNDKYGI | | SSGDAGSTFM | | ERGVKNKQDF | | MDLSICTREK | | LAHVRNCKTG |
SSGIPVKLVT | | NLFNLDFPQD | | WQLYQYHVTY | | IPDLASRRLR | | IALLYSHSEL |
SNKAKAFDGA | | ILFLSQKLEE | | KVTELSSETQ | | RGETIKMTIT | | LKRELPSSSP |
VCIQVFNIIF | | RKILKKLSMY | | QIGRNFYNPS | | EPMEIPQHKL | | SLWPGFAISV |
SYFERKLLFS | | ADVSYKVLRN | | ETVLEFMTAL | | CQRTGLSCFT | | QTCEKQLIGL |
IVLTRYNNRT | | YSIDDIDWSV | | KPTHTFQKRD | | GTEITYVDYY | | KQQYDITVSD |
LNQPMLVSLL | | KKKRNDNSEA | | QLAHLIPELC | | FLTGLTDQAT | | SDFQLMKAVA |
EKTRLSPSGR | | QQRLARLVDN | | IQRNTNARFE | | LETWGLHFGS | | QISLTGRIVP |
SEKILMQDHI | | CQPVSAADWS | | KDIRTCKILN | | AQSLNTWLIL | | CSDRTEYVAE |
SFLNCLRRVA | | GSMGFNVDYP | | KIIKVQENPA | | AFVRAIQQYV | | DPDVQLVMCI |
LPSNQKTYYD | | SIKKYLSSDC | | PVPSQCVLAR | | TLNKQGMMMS | | IATKIAMQMT |
CKLGGELWAV | | EIPLKSLMVV | | GIDVCKDALS | | KDVMVVGCVA | | SVNPRITRWF |
SRCILQRTMT | | DVADCLKVFM | | TGALNKWYKY | | NHDLPARIIV | | YRAGVGDGQL |
KTLIEYEVPQ | | LLSSVAESSS | | NTSSRLSVIV | | VRKKCMPRFF | | TEMNRTVQNP |
PLGTVVDSEA | | TRNEWYDFYL | | ISQVACRGTV | | SPTYYNVIYD | | DNGLKPDHMQ |
RLTFKLCHLY | | YNWPGIVSVP | | APCQYAHKLT | | FLVAQSIHKE | | PSLELANHLF |
YL |
PIWIL4 pripada porodici argonautskih proteina, koji funkcionišu u razvoju i održavanju matičnih ćelija zametne linije (Sasaki et al., 2003 PubMed 12906857]).
- Sugimoto K, Kage H, Aki N, Sano A, Kitagawa H, Nagase T, Yatomi Y, Ohishi N, Takai D (2007). "The induction of H3K9 methylation by PIWIL4 at the p16Ink4a locus". Biochem. Biophys. Res. Commun. 359 (3): 497–502. doi:10.1016/j.bbrc.2007.05.136. PMID 17544373.
- Li L, Yu C, Gao H, Li Y (2010). "Argonaute proteins: potential biomarkers for human colon cancer". BMC Cancer. 10: 38. doi:10.1186/1471-2407-10-38. PMC 2843668. PMID 20146808.
- Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
- Kim JS, Choi YY, Jin G, Kang HG, Choi JE, Jeon HS, Lee WK, Kim DS, Kim CH, Kim YJ, Son JW, Jung TH, Park JY (2010). "Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study". Mol. Carcinog. 49 (10): 913–21. doi:10.1002/mc.20672. PMID 20721975. S2CID 206233924.
- Gu A, Ji G, Shi X, Long Y, Xia Y, Song L, Wang S, Wang X (2010). "Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population". Hum. Reprod. 25 (12): 2955–61. doi:10.1093/humrep/deq274. PMID 20940137.
- Gu A, Ji G, Shi X, Long Y, Xia Y, Song L, Wang S, Wang X (2010). "Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population". Hum. Reprod. 25 (12): 2955–61. doi:10.1093/humrep/deq274. PMID 20940137.
- Su C, Ren ZJ, Wang F, Liu M, Li X, Tang H (2012). "PIWIL4 regulates cervical cancer cell line growth and is involved in down-regulating the expression of p14ARF and p53". FEBS Lett. 586 (9): 1356–62. doi:10.1016/j.febslet.2012.03.053. PMID 22483988. S2CID 45962616.
- Greither T, Koser F, Kappler M, Bache M, Lautenschläger C, Göbel S, Holzhausen HJ, Wach S, Würl P, Taubert H (2012). "Expression of human Piwi-like genes is associated with prognosis for soft tissue sarcoma patients". BMC Cancer. 12: 272. doi:10.1186/1471-2407-12-272. PMC 3472179. PMID 22748119.
- Bao J, Zhang Y, Schuster AS, Ortogero N, Nilsson EE, Skinner MK, Yan W (2014). "Conditional inactivation of Miwi2 reveals that MIWI2 is only essential for prospermatogonial development in mice". Cell Death Differ. 21 (5): 783–96. doi:10.1038/cdd.2014.5. PMC 3978311. PMID 24464225.