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Član 14 porodice poli(ADP-riboza) polimeraza jest protein/enzim koji je kod ljudi kodiran genom PARP14 sa hromosoma 3.[5]
Dužina polipeptidnog lanca je 1.801 aminokiselina, а molekulska težina 202.800 Da.[6]
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MAVPGSFPLL | VEGSWGPDPP | KNLNTKLQMY | FQSPKRSGGG | ECEVRQDPRS | ||||
PSRFLVFFYP | EDVRQKVLER | KNHELVWQGK | GTFKLTVQLP | ATPDEIDHVF | ||||
EEELLTKESK | TKEDVKEPDV | SEELDTKLPL | DGGLDKMEDI | PEECENISSL | ||||
VAFENLKANV | TDIMLILLVE | NISGLSNDDF | QVEIIRDFDV | AVVTFQKHID | ||||
TIRFVDDCTK | HHSIKQLQLS | PRLLEVTNTI | RVENLPPGAD | DYSLKLFFEN | ||||
PYNGGGRVAN | VEYFPEESSA | LIEFFDRKVL | DTIMATKLDF | NKMPLSVFPY | ||||
YASLGTALYG | KEKPLIKLPA | PFEESLDLPL | WKFLQKKNHL | IEEINDEMRR | ||||
CHCELTWSQL | SGKVTIRPAA | TLVNEGRPRI | KTWQADTSTT | LSSIRSKYKV | ||||
NPIKVDPTMW | DTIKNDVKDD | RILIEFDTLK | EMVILAGKSE | DVQSIEVQVR | ||||
ELIESTTQKI | KREEQSLKEK | MIISPGRYFL | LCHSSLLDHL | LTECPEIEIC | ||||
YDRVTQHLCL | KGPSADVYKA | KCEIQEKVYT | MAQKNIQVSP | EIFQFLQQVN | ||||
WKEFSKCLFI | AQKILALYEL | EGTTVLLTSC | SSEALLEAEK | QMLSALNYKR | ||||
IEVENKEVLH | GKKWKGLTHN | LLKKQNSSPN | TVIINELTSE | TTAEVIITGC | ||||
VKEVNETYKL | LFNFVEQNMK | IERLVEVKPS | LVIDYLKTEK | KLFWPKIKKV | ||||
NVQVSFNPEN | KQKGILLTGS | KTEVLKAVDI | VKQVWDSVCV | KSVHTDKPGA | ||||
KQFFQDKARF | YQSEIKRLFG | CYIELQENEV | MKEGGSPAGQ | KCFSRTVLAP | ||||
GVVLIVQQGD | LARLPVDVVV | NASNEDLKHY | GGLAAALSKA | AGPELQADCD | ||||
QIVKREGRLL | PGNATISKAG | KLPYHHVIHA | VGPRWSGYEA | PRCVYLLRRA | ||||
VQLSLCLAEK | YKYRSIAIPA | ISSGVFGFPL | GRCVETIVSA | IKENFQFKKD | ||||
GHCLKEIYLV | DVSEKTVEAF | AEAVKTVFKA | TLPDTAAPPG | LPPAAAGPGK | ||||
TSWEKGSLVS | PGGLQMLLVK | EGVQNAKTDV | VVNSVPLDLV | LSRGPLSKSL | ||||
LEKAGPELQE | ELDTVGQGVA | VSMGTVLKTS | SWNLDCRYVL | HVVAPEWRNG | ||||
STSSLKIMED | IIRECMEITE | SLSLKSIAFP | AIGTGNLGFP | KNIFAELIIS | ||||
EVFKFSSKNQ | LKTLQEVHFL | LHPSDHENIQ | AFSDEFARRA | NGNLVSDKIP | ||||
KAKDTQGFYG | TVSSPDSGVY | EMKIGSIIFQ | VASGDITKEE | ADVIVNSTSN | ||||
SFNLKAGVSK | AILECAGQNV | ERECSQQAQQ | RKNDYIITGG | GFLRCKNIIH | ||||
VIGGNDVKSS | VSSVLQECEK | KNYSSICLPA | IGTGNAKQHP | DKVAEAIIDA | ||||
IEDFVQKGSA | QSVKKVKVVI | FLPQVLDVFY | ANMKKREGTQ | LSSQQSVMSK | ||||
LASFLGFSKQ | SPQKKNHLVL | EKKTESATFR | VCGENVTCVE | YAISWLQDLI | ||||
EKEQCPYTSE | DECIKDFDEK | EYQELNELQK | KLNINISLDH | KRPLIKVLGI | ||||
SRDVMQARDE | IEAMIKRVRL | AKEQESRADC | ISEFIEWQYN | DNNTSHCFNK | ||||
MTNLKLEDAR | REKKKTVDVK | INHRHYTVNL | NTYTATDTKG | HSLSVQRLTK | ||||
SKVDIPAHWS | DMKQQNFCVV | ELLPSDPEYN | TVASKFNQTC | SHFRIEKIER | ||||
IQNPDLWNSY | QAKKKTMDAK | NGQTMNEKQL | FHGTDAGSVP | HVNRNGFNRS | ||||
YAGKNAVAYG | KGTYFAVNAN | YSANDTYSRP | DANGRKHVYY | VRVLTGIYTH | ||||
GNHSLIVPPS | KNPQNPTDLY | DTVTDNVHHP | SLFVAFYDYQ | AYPEYLITFR | ||||
K |
Poli(ADP-ribozil)acija je neposredna DNK-ovisna o oštećenju posttranslacijska modifikacija histon a i drugih jedarnih proteina koja doprinosi preživljavanju oštećenih ćelija koje se razmnožavaju. PARP14 pripada natporodici enzima koji izvode ovu modifikaciju (Ame et al., 2004 PubMed 15273990).
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