NPM3

NPM3
Identifikatori
Aliasi	NPM3
Vanjski ID-jevi	OMIM: 606456 MGI: 894653 HomoloGene: 5083 GeneCards: NPM3
Lokacija gena (čovjek)
Hrom.	Hromosom 10 (čovjek)
Kraj	101,783,413 bp
Lokacija gena (miš)
Hrom.	Hromosom 19 (miš)
Kraj	45,738,030 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje sa RNK; • chromatin binding; • GO:0031493 histone binding;
Ćelijska komponenta	• jedro; • Jedarce; • citosol; • actin cytoskeleton; • nukleoplazma; • citoplazma;
Biološki proces	• rRNA processing; • rRNA transcription; • chromatin remodeling;
	Izvori:Amigo / QuickGO
Ortolozi
	10360
	18150
	ENSG00000107833
	ENSMUSG00000056209
	O75607
	Q9CPP0
	NM_006993
	NM_008723
	NP_008924
	NP_032749
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Nukleoplazmin-3 je protein koji je kod ljudi kodiran genom NPM3.^[5]^[6]

Kratke činjenice Identifikatori, Aliasi ...

Zatvori

Dužina polipeptidnog lanca je 178 aminokiselina, а molekulska težina 19.344 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAAGTAAALA	FLSQESRTRA	GGVGGLRVPA	PVTMDSFFFG	CELSGHTRSF
TFKVEEEDDA	EHVLALTMLC	LTEGAKDECN	VVEVVARNHD	HQEIAVPVAN
LKLSCQPMLS	LDDFQLQPPV	TFRLKSGSGP	VRITGRHQIV	TMSNDVSEEE
SEEEEEDSDE	EEVELCPILP	AKKQGGRP

Protein kodiran ovim genom povezan je s jedarnim šaperonskim fosfoproteinima, nukleoplazminom i nukleofosminom. Vrlo je homologan produktu mišjeg gena Npm3. Na temelju strukturne sličnosti ljudskog genskog proizvoda NPM3 s nukleoplazminom i nukleofosminom, NPM3 može predstavljati novog člana ove genske porodice i može dijeliti osnovne funkcije s molekulskim šaperonima.^[6]

[1]
GRCh38: Ensembl release 89: ENSG00000107833 - Ensembl, maj 2017
[2]
GRCm38: Ensembl release 89: ENSMUSG00000056209 - Ensembl, maj 2017
[3]
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
[4]
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
[5]
Shackleford GM, Ganguly A, MacArthur CA (Jul 2003). "Cloning, expression and nuclear localization of human NPM3, a member of the nucleophosmin/nucleoplasmin family of nuclear chaperones". BMC Genomics. 2: 8. doi:10.1186/1471-2164-2-8. PMC 60000. PMID 11722795.
[6]
"Entrez Gene: NPM3 nucleophosmin/nucleoplasmin, 3".
[7]
"UniProt, O75607". Pristupljeno 3. 9. 2021.

Philpott A, Krude T, Laskey RA (2000). "Nuclear chaperones". Semin. Cell Dev. Biol. 11 (1): 7–14. doi:10.1006/scdb.1999.0346. PMID 10736259.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
MacArthur CA, Shackleford GM (1997). "Npm3: a novel, widely expressed gene encoding a protein related to the molecular chaperones nucleoplasmin and nucleophosmin". Genomics. 42 (1): 137–40. doi:10.1006/geno.1997.4353. PMID 9177783.

NPM3 lokacija ljudskog genoma UCSC Genome Browser.

NPM3 detalji ljudskog genoma u UCSC Genome Browser.

[refGRCh38Ensembl-1] [1]
GRCh38: Ensembl release 89: ENSG00000107833 - Ensembl, maj 2017

[refGRCm38Ensembl-2] [2]
GRCm38: Ensembl release 89: ENSMUSG00000056209 - Ensembl, maj 2017

[3] [3]
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] [4]
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11722795-5] [5]
Shackleford GM, Ganguly A, MacArthur CA (Jul 2003). "Cloning, expression and nuclear localization of human NPM3, a member of the nucleophosmin/nucleoplasmin family of nuclear chaperones". BMC Genomics. 2: 8. doi:10.1186/1471-2164-2-8. PMC 60000. PMID 11722795.

[entrez-6] [6]
"Entrez Gene: NPM3 nucleophosmin/nucleoplasmin, 3".

[UniProt-7] [7]
"UniProt, O75607". Pristupljeno 3. 9. 2021.

[5]

[6]

[1]

[2]

[3]

[4]

[7]

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NPM3

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Aminokiselinska sekvenca

Funkcija

Reference

Dopunska literatura

Vanjski linkovi