LRRC48

Protein 48 sa ponavljanjem i bogat leucinom je protein koji je kod ljudi kodiran genom LRRC48.^[5][6][7]

LRRC48
Identifikatori
Aliasi	DRC3
Vanjski ID-jevi	MGI: 1921915 HomoloGene: 12581 GeneCards: DRC3
Lokacija gena (čovjek) Hrom. Hromosom 17 (čovjek)[1] Bend 17p11.2|17p11.2 Početak 17,972,813 bp[1] Kraj 18,016,889 bp[1]
Lokacija gena (miš) Hrom. Hromosom 11 (miš)[2] Bend 11|11 B2 Početak 60,244,155 bp[2] Kraj 60,285,167 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ortolozi
Vrste	Čovjek	Miš
Entrez	83450	74665
Ensembl	ENSG00000171962	ENSMUSG00000056598
UniProt	Q9H069	Q9D5E4
RefSeq (mRNK)	NM_001130090 NM_001130091 NM_001130092 NM_031294	NM_029044
RefSeq (bjelančevina)	NP_001123562 NP_001123563 NP_001123564 NP_112584	NP_083320
Lokacija (UCSC)	Chr 17: 17.97 – 18.02 Mb	Chr 11: 60.24 – 60.29 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Dužina polipeptidnog lanca je 523 aminokiseline, sa molekulskom težinom od 61.054.^[8]

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MNQPCNSMEP		RVMDDDMLKL		AVGDQGPQEE		AGQLAKQEGI		LFKDVLSLQL
DFRNILRIDN		LWQFENLRKL		QLDNNIIEKI		EGLENLAHLV		WLDLSFNNIE
TIEGLDTLVN		LEDLSLFNNR		ISKIDSLDAL		VKLQVLSLGN		NRIDNMMNII
YLRRFKCLRT		LSLSRNPISE		AEDYKMFICA		YLPDLMYLDY		RRIDDHTKKL
AEAKHQYSID		ELKHQENLMQ		AQLEDEQAQR		EELEKHKTAF		VEHLNGSFLF
DSMYAEDSEG		NNLSYLPGVG		ELLETYKDKF		VIICVNIFEY		GLKQQEKRKT
ELDTFSECVR		EAIQENQEQG		KRKIAKFEEK		HLSSLSAIRE		ELELPNIEKM
ILECSADISE		LFDALMTLEM		QLVEQLEETI		NMFERNIVDM		VGLFIENVQS
LMAQCRDLEN		HHHEKLLEIS		ISTLEKIVEG		DLDEDLPNDL		RALFVDKDTI
VNAVGASHDI		HLLKIDNRED		ELVTRINSWC		TRLIDRIHKD		EIMRNRKRVK
EINQYIDHMQ		SELDNLECGD		ILD

Reference

1. GRCh38: Ensembl release 89: ENSG00000171962 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000056598 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
6. Bi W, Yan J, Stankiewicz P, Park SS, Walz K, Boerkoel CF, Potocki L, Shaffer LG, Devriendt K, Nowaczyk MJ, Inoue K, Lupski JR (maj 2002). "Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse". Genome Res. 12 (5): 713–28. doi:10.1101/gr.73702. PMC 186594. PMID 11997338.
7. "Entrez Gene: LRRC48 leucine rich repeat containing 48".
8. "UniProt, Q9H069". Pristupljeno 12. 9. 2017.

Dopunska literatura

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Lucas RE, Vlangos CN, Das P, et al. (2002). "Genomic organisation of the approximately 1.5 Mb Smith-Magenis syndrome critical interval: transcription map, genomic contig, and candidate gene analysis". Eur. J. Hum. Genet. 9 (12): 892–902. doi:10.1038/sj.ejhg.5200734. PMID 11840190.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.