Protein 15 sa leucinom bogatim ponavljanjem jest protein koji je kod ljudi kodiran genom LRRC15 sa hromosoma 3.[5]
Kratke činjenice Identifikatori, Aliasi ...
Zatvori
Dužina polipeptidnog lanca je 581 aminokiselina, а molekulska težina 64.366 Da.[6].
| 10 | | 20 | | 30 | | 40 | | 50 |
|---|
| MPLKHYLLLL | | VGCQAWGAGL | | AYHGCPSECT | | CSRASQVECT | | GARIVAVPTP |
| LPWNAMSLQI | | LNTHITELNE | | SPFLNISALI | | ALRIEKNELS | | RITPGAFRNL |
| GSLRYLSLAN | | NKLQVLPIGL | | FQGLDSLESL | | LLSSNQLLQI | | QPAHFSQCSN |
| LKELQLHGNH | | LEYIPDGAFD | | HLVGLTKLNL | | GKNSLTHISP | | RVFQHLGNLQ |
| VLRLYENRLT | | DIPMGTFDGL | | VNLQELALQQ | | NQIGLLSPGL | | FHNNHNLQRL |
| YLSNNHISQL | | PPSVFMQLPQ | | LNRLTLFGNS | | LKELSPGIFG | | PMPNLRELWL |
| YDNHISSLPD | | NVFSNLRQLQ | | VLILSRNQIS | | FISPGAFNGL | | TELRELSLHT |
| NALQDLDGNV | | FRMLANLQNI | | SLQNNRLRQL | | PGNIFANVNG | | LMAIQLQNNQ |
| LENLPLGIFD | | HLGKLCELRL | | YDNPWRCDSD | | ILPLRNWLLL | | NQPRLGTDTV |
| PVCFSPANVR | | GQSLIIINVN | | VAVPSVHVPE | | VPSYPETPWY | | PDTPSYPDTT |
| SVSSTTELTS | | PVEDYTDLTT | | IQVTDDRSVW | | GMTQAQSGLA | | IAAIVIGIVA |
| LACSLAACVG | | CCCCKKRSQA | | VLMQMKAPNE | | C |
- Reynolds PA, Smolen GA, Palmer RE, Sgroi D, Yajnik V, Gerald WL, Haber DA (septembar 2003). "Identification of a DNA-binding site and transcriptional target for the EWS-WT1(+KTS) oncoprotein". Genes & Development. 17 (17): 2094–107. doi:10.1101/gad.1110703. PMC 196452. PMID 12923058.
- Dominguez CX, Müller S, Keerthivasan S, Koeppen H, Hung J, Gierke S, Breart B, Foreman O, Bainbridge TW, Castiglioni A, Senbabaoglu Y, Modrusan Z, Liang Y, Junttila MR, Klijn C, Bourgon R, Turley SJ (februar 2020). "Single-Cell RNA Sequencing Reveals Stromal Evolution into LRRC15+ Myofibroblasts as a Determinant of Patient Response to Cancer Immunotherapy". Cancer Discovery. 10 (2): 232–253. doi:10.1158/2159-8290.CD-19-0644. PMID 31699795.
- Buechler MB, Pradhan RN, Krishnamurty AT, Cox C, Calviello AK, Wang AW, Yang YA, Tam L, Caothien R, Roose-Girma M, Modrusan Z, Arron JR, Bourgon R, Müller S, Turley SJ (maj 2021). "Cross-tissue organization of the fibroblast lineage". Nature. 593 (7860): 575–579. doi:10.1038/s41586-021-03549-5. PMID 33981032 .
- Wang Y, Liu Y, Zhang M, Lv L, Zhang X, Zhang P, Zhou Y (mart 2018). "LRRC15 promotes osteogenic differentiation of mesenchymal stem cells by modulating p65 cytoplasmic/nuclear translocation". Stem Cell Res Ther. 9 (1): 65. doi:10.1186/s13287-018-0809-1. PMC 5845373. PMID 29523191.
- Cui J, Dean D, Wei R, Hornicek FJ, Ulmert D, Duan Z (septembar 2020). "Expression and Clinical Implications of Leucine-Rich Repeat Containing 15 (LRRC15) in Osteosarcoma". J Orthop Res. doi:10.1002/jor.24848. PMID 32902907.
- O'Prey J, Wilkinson S, Ryan KM (juni 2008). "Tumor antigen LRRC15 impedes adenoviral infection: implications for virus-based cancer therapy". Journal of Virology. 82 (12): 5933–9. doi:10.1128/JVI.02273-07. PMC 2395123. PMID 18385238.
- Satoh K, Hata M, Yokota H (januar 2002). "A novel member of the leucine-rich repeat superfamily induced in rat astrocytes by beta-amyloid". Biochemical and Biophysical Research Communications. 290 (2): 756–62. doi:10.1006/bbrc.2001.6272. PMID 11785964.
- Satoh K, Hata M, Shimizu T, Yokota H, Akatsu H, Yamamoto T, Kosaka K, Yamada T (septembar 2005). "Lib, transcriptionally induced in senile plaque-associated astrocytes, promotes glial migration through extracellular matrix". Biochemical and Biophysical Research Communications. 335 (2): 631–6. doi:10.1016/j.bbrc.2005.07.117. PMID 16098915.
