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Gama-interferonski inducibilna liozosomska tiol-reduktaza je enzim koji je kod ljudi kodiran genom IFI30.[5][6][7]
Protein koji je kodiran ovim genom je lizosomna tiol-reduktaza, koja pri niskom pH može smanjiti proteinske disulfidne veze. Enzim se konstitutivno eksprimira u ćelijama koje prezentiraju antigen, a u drugim tipovima ćelija inducira ga gama-interferon. Ovaj enzim ima važnu ulogu u MHC klasi II obrade antigena.[7]
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MTLSPLLLFL | PPLLLLLDVP | TAAVQASPLQ | ALDFFGNGPP | VNYKTGNLYL | ||||
RGPLKKSNAP | LVNVTLYYEA | LCGGCRAFLI | RELFPTWLLV | MEILNVTLVP | ||||
YGNAQEQNVS | GRWEFKCQHG | EEECKFNKVE | ACVLDELDME | LAFLTIVCME | ||||
EFEDMERSLP | LCLQLYAPGL | SPDTIMECAM | GDRGMQLMHA | NAQRTDALQP | ||||
PHEYVPWVTV | NGKPLEDQTQ | LLTLVCQLYQ | GKKPDVCPSS | TSSLRSVCFK | ||||
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