HTATIP2

Oksidoreduktaza HTATIP2 je enzim koji je kod ljudi kodiran genom HTATIP2.^[5][6][7][8] Može biti supresor metastaza.

HTATIP2
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2BKA
Identifikatori
Aliasi	HTATIP2
Vanjski ID-jevi	OMIM: 605628 MGI: 1859271 HomoloGene: 4676 GeneCards: HTATIP2
Lokacija gena (čovjek) Hrom. Hromosom 11 (čovjek)[1] Bend 11p15.1 Početak 20,363,685 bp[1] Kraj 20,383,782 bp[1]
Lokacija gena (miš) Hrom. Hromosom 7 (miš)[2] Bend 7|7 B4 Početak 49,408,863 bp[2] Kraj 49,423,723 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • oxidoreductase activity • GO:0001105 transcription coactivator activity • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • citoplazma • nuclear envelope • membrana • jedro • citosol Biološki proces • multicellular organism development • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • Ćelijska diferencijacija • GO:0022415 viral process • negative regulation of apoptotic process • regulation of angiogenesis • Angiogeneza • import into nucleus • GO:0097285 apoptoza • positive regulation of nucleic acid-templated transcription Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	10553	53415
Ensembl	ENSG00000109854	ENSMUSG00000039745
UniProt	Q9BUP3	Q9Z2G9
RefSeq (mRNK)	NM_006410 NM_001098520 NM_001098521 NM_001098522 NM_001098523	NM_001146049 NM_001146050 NM_001146052 NM_001146053 NM_016865
RefSeq (bjelančevina)	NP_001091990 NP_001091991 NP_001091992 NP_001091993 NP_006401	NP_001139521 NP_001139522 NP_001139524 NP_001139525 NP_058561
Lokacija (UCSC)	Chr 11: 20.36 – 20.38 Mb	Chr 7: 49.41 – 49.42 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 242 aminokiseline, a molekulska težina 27.049 Da.^[9]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MAETEALSKL		REDFRMQNKS		VFILGASGET		GRVLLKEILE		QGLFSKVTLI
GRRKLTFDEE		AYKNVNQEVV		DFEKLDDYAS		AFQGHDVGFC		CLGTTRGKAG
AEGFVRVDRD		YVLKSAELAK		AGGCKHFNLL		SSKGADKSSN		FLYLQVKGEV
EAKVEELKFD		RYSVFRPGVL		LCDRQESRPG		EWLVRKFFGS		LPDSWASGHS
VPVVTVVRAM		LNNVVRPRDK		QMELLENKAI		HDLGKAHGSL		KP

Reference

1. GRCh38: Ensembl release 89: ENSG00000109854 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039745 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Xiao H, Tao Y, Greenblatt J, Roeder RG (Apr 1998). "A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription". Proc Natl Acad Sci U S A. 95 (5): 2146–51. doi:10.1073/pnas.95.5.2146. PMC 19278. PMID 9482853.
6. Shtivelman E (Jun 1997). "A link between metastasis and resistance to apoptosis of variant small cell lung carcinoma". Oncogene. 14 (18): 2167–73. doi:10.1038/sj.onc.1201059. PMID 9174052.
7. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
8. "Entrez Gene: HTATIP2 HIV-1 Tat interactive protein 2, 30kDa".
9. "UniProt, Q9BUP3". Pristupljeno 23. 8. 2021.

Dopunska literatura

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Baker ME (1999). "TIP30, a cofactor for HIV-1 Tat-activated transcription, is homologous to short-chain dehydrogenases/reductases". Curr. Biol. 9 (13): R471. doi:10.1016/S0960-9822(99)80297-8. PMID 10395547. S2CID 7740085.
• Whitman S, Wang X, Shalaby R, Shtivelman E (2000). "Alternatively spliced products CC3 and TC3 have opposing effects on apoptosis". Mol. Cell. Biol. 20 (2): 583–93. doi:10.1128/MCB.20.2.583-593.2000. PMC 85138. PMID 10611237.
• Xiao H, Palhan V, Yang Y, Roeder RG (2000). "TIP30 has an intrinsic kinase activity required for up-regulation of a subset of apoptotic genes". EMBO J. 19 (5): 956–63. doi:10.1093/emboj/19.5.956. PMC 305635. PMID 10698937.
• Baker ME, Yan L, Pear MR (2000). "Three-dimensional model of human TIP30, a coactivator for HIV-1 Tat-activated transcription, and CC3, a protein associated with metastasis suppression". Cell. Mol. Life Sci. 57 (5): 851–8. doi:10.1007/s000180050047. PMID 10892349. S2CID 25141732.
• NicAmhlaoibh R, Shtivelman E (2001). "Metastasis suppressor CC3 inhibits angiogenic properties of tumor cells in vitro". Oncogene. 20 (2): 270–5. doi:10.1038/sj.onc.1204075. PMID 11313954.
• Ito M, Jiang C, Krumm K, Zhang X, Pecha J, Zhao J, Guo Y, Roeder RG, Xiao H (2004). "TIP30 deficiency increases susceptibility to tumorigenesis". Cancer Res. 63 (24): 8763–7. PMID 14695192.
• Jiang C, Ito M, Piening V, Bruck K, Roeder RG, Xiao H (2004). "TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription". J. Biol. Chem. 279 (26): 27781–9. doi:10.1074/jbc.M401809200. PMID 15073177.
• Tsutsumi S, Kamata N, Vokes TJ, Maruoka Y, Nakakuki K, Enomoto S, Omura K, Amagasa T, Nagayama M, Saito-Ohara F, Inazawa J, Moritani M, Yamaoka T, Inoue H, Itakura M (2004). "The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD)". Am. J. Hum. Genet. 74 (6): 1255–61. doi:10.1086/421527. PMC 1182089. PMID 15124103.
• King FW, Shtivelman E (2004). "Inhibition of nuclear import by the proapoptotic protein CC3". Mol. Cell. Biol. 24 (16): 7091–101. doi:10.1128/MCB.24.16.7091-7101.2004. PMC 479715. PMID 15282309.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Sun L, Feng S, Reséndiz JC, Lu X, Durante W, Kroll MH (2005). "Role of the Pyk2-MAP kinase-cPLA2 signaling pathway in shear-dependent platelet aggregation". Annals of Biomedical Engineering. 32 (9): 1193–201. doi:10.1114/B:ABME.0000039353.97347.28. PMID 15493507. S2CID 31410967.
• Shi M, Zhang X, Wang P, Zhang HW, Zhang BH, Wu MC (2005). "TIP30 regulates apoptosis-related genes in its apoptotic signal transduction pathway". World J. Gastroenterol. 11 (2): 221–7. doi:10.3748/wjg.v11.i2.221. PMC 4205406. PMID 15633220.
• El Omari K, Bird LE, Nichols CE, Ren J, Stammers DK (2005). "Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor". J. Biol. Chem. 280 (18): 18229–36. doi:10.1074/jbc.M501113200. PMID 15728189.
• Caldwell RL, Lane KB, Shepherd VL (2006). "HIV-1 Tat interaction with cyclin T1 represses mannose receptor and the bone morphogenetic protein receptor-2 transcription". Arch. Biochem. Biophys. 449 (1–2): 27–33. doi:10.1016/j.abb.2006.02.020. PMID 16615932.

Vanjski linkovi