HEMK1

Član 1 porodice HemK-metiltransferaza jest enzim koji je kod ljudi kodiran genom HEMK1 sa hromosoma 3.^[5]

HEMK1
Identifikatori
Aliasi	HEMK1
Vanjski ID-jevi	MGI: 1916786 HomoloGene: 6815 GeneCards: HEMK1
Lokacija gena (čovjek) Hrom. Hromosom 3 (čovjek)[1] Bend 3p21.31 Početak 50,569,152 bp[1] Kraj 50,596,168 bp[1]
Lokacija gena (miš) Hrom. Hromosom 9 (miš)[2] Bend 9|9 F1 Početak 107,327,084 bp[2] Kraj 107,338,350 bp[2]
Ontologija gena Molekularna funkcija • N-methyltransferase activity • vezivanje sa DNK • nucleic acid binding • GO:0102674, GO:0102675 methyltransferase activity • protein methyltransferase activity • aktivnost sa transferazom • GO:0001948, GO:0016582 vezivanje za proteine • S-adenosylmethionine-dependent methyltransferase activity • protein-(glutamine-N5) methyltransferase activity Ćelijska komponenta • mitohondrija Biološki proces • Metilacija DNK • protein methylation • Metilacija Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	51409	69536
Ensembl	ENSG00000114735	ENSMUSG00000032579
UniProt	Q9Y5R4	Q921L7
RefSeq (mRNK)	NM_016173 NM_001317851 NM_001377420 NM_001377421 NM_001377422 NM_001377423 NM_001377424 NM_001377425 NM_001377426 NM_001377427 NM_001377428 NM_001377429	NM_133984
RefSeq (bjelančevina)	NP_001304780 NP_057257 NP_001364349 NP_001364350 NP_001364351 NP_001364352 NP_001364353 NP_001364354 NP_001364355 NP_001364356 NP_001364357 NP_001364358	NP_598745
Lokacija (UCSC)	Chr 3: 50.57 – 50.6 Mb	Chr 9: 107.33 – 107.34 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 338 aminokiselina, а molekulska težina 38.231 Da.^[6]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MELWGRMLWA		LLSGPGRRGS		TRGWAFSSWQ		PQPPLAGLSS		AIELVSHWTG
VFEKRGIPEA		RESSEYIVAH		VLGAKTFQSL		RPALWTQPLT		SQQLQCIREL
SSRRLQRMPV		QYILGEWDFQ		GLSLRMVPPV		FIPRPETEEL		VEWVLEEVAQ
RSHAVGSPGS		PLILEVGCGS		GAISLSLLSQ		LPQSRVIAVD		KREAAISLTH
ENAQRLRLQD		RIWIIHLDMT		SERSWTHLPW		GPMDLIVSNP		PYVFHQDMEQ
LAPEIRSYED		PAALDGGEEG		MDIITHILAL		APRLLKDSGS		IFLEVDPRHP
ELVSSWLQSR		PDLYLNLVAV		RRDFCGRPRF		LHIRRSGP

Reference

1. GRCh38: Ensembl release 89: ENSG00000114735 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032579 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: HemK methyltransferase family member 1". Pristupljeno 25. 9. 2015.
6. "UniProt, Q9Y5R4" (jezik: engleski). Pristupljeno 4. 11. 2021.

Vanjski linkovi