Pretvarač signala hematopoetskih ćelija ili tranduktor signala hematopoetskih signala je protein koji je dod ljudi kodiran genom HCST.[5][6]
Kratke činjenice Identifikatori, Aliasi ...
Zatvori
Ovaj gen kodira transmembranski signalni adapter koji sadrži YxxM motiv u svojoj citoplazmatskom domenu. Kodirani protein može činiti dio kompleksa receptora imunskog prepoznavanja sa receptorom sličnim lektinu C tipa NKG2D. Kao dio ovog receptorskog kompleksa, ovaj protein može aktivirati signalne puteve ovisne o fosfatidilinozitol 3-kinazi, preko svog intracitoplazmatskog motiva YxxM.
Ovaj receptorski kompleks može imati ulogu u preživljavanju i proliferaciji ćelija, aktivacijom odgovora NK i T-ćelija. Alternativna prerada rezultira u dvije varijante transkripta, koji kodiraju različite izoforme.[6]
- Simboli
10 | | 20 | | 30 | | 40 | | 50 |
MIHLGHILFL | | LLLPVAAAQT | | TPGERSSLPA | | FYPGTSGSCS | | GCGSLSLPLL |
AGLVAADAVA | | SLLIVGAVFL | | CARPRRSPAQ | | EDGKVYINMP | | GRG |
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