Receptoliki fibroblastni faktor rasta 1 jest protein koji je kod ljudi kodiran genom sa hromosoma 4.[5]
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Zatvori
Dužina polipeptidnog lanca je 504 aminokiselina, а molekulska težina 54.537 Da.[6].
| 10 | | 20 | | 30 | | 40 | | 50 |
|---|
| MTPSPLLLLL | | LPPLLLGAFP | | PAAAARGPPK | | MADKVVPRQV | | ARLGRTVRLQ |
| CPVEGDPPPL | | TMWTKDGRTI | | HSGWSRFRVL | | PQGLKVKQVE | | REDAGVYVCK |
| ATNGFGSLSV | | NYTLVVLDDI | | SPGKESLGPD | | SSSGGQEDPA | | SQQWARPRFT |
| QPSKMRRRVI | | ARPVGSSVRL | | KCVASGHPRP | | DITWMKDDQA | | LTRPEAAEPR |
| KKKWTLSLKN | | LRPEDSGKYT | | CRVSNRAGAI | | NATYKVDVIQ | | RTRSKPVLTG |
| THPVNTTVDF | | GGTTSFQCKV | | RSDVKPVIQW | | LKRVEYGAEG | | RHNSTIDVGG |
| QKFVVLPTGD | | VWSRPDGSYL | | NKLLITRARQ | | DDAGMYICLG | | ANTMGYSFRS |
| AFLTVLPDPK | | PPGPPVASSS | | SATSLPWPVV | | IGIPAGAVFI | | LGTLLLWLCQ |
| AQKKPCTPAP | | APPLPGHRPP | | GTARDRSGDK | | DLPSLAALSA | | GPGVGLCEEH |
| GSPAAPQHLL | | GPGPVAGPKL | | YPKLYTDIHT | | HTHTHSHTHS | | HVEGKVHQHI |
| HYQC |
Protein kodiran ovim genom je član porodice receptor faktora rasta fibroblasta (FGFR), gdje je sekvenca aminokiselina visoko konzervirana između članova i tokom evolucije. Članovi porodice FGFR razlikuju se međusobno po afinitetima liganda i tkivnoj distribuciji. Reprezentativni protein pune dužine sastojao bi se od vanćelijskog regiona, sastavljenog od tri domena slična imunoglobulinu, jednog hidrofobnog segmenta koji pokriva membranu i domena citoplazmatske tirozin-kinaze. Vanćelijski dio proteina stupa u interakciju s faktorima rasta fibroblasta, pokrećući kaskadu nizvodnih signala, na kraju utičući na mitogenezu i diferencijaciju. Značajna razlika između ovog genskog proizvoda i ostalih članova porodice je nedostatak domena citoplazmatske tirozin-kinaze. Rezultat je transmembranski receptor koji može stupiti u interakciju s drugim članovima porodice i potencijalno inhibirati signalizaciju. Za ovaj gen pronađene su višestruke alternativno prerađene varijante transkripta koje kodiraju istu izoformu.[5]
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