Pojačivač polikombnog homologa 1 je protein koji je kod ljudig kodoran genom EPC1.[5][6]
Kratke činjenice Identifikatori, Aliasi ...
EPC1 |
---|
|
Identifikatori |
---|
Aliasi | EPC1 |
---|
Vanjski ID-jevi | OMIM: 610999 MGI: 1278322 HomoloGene: 32627 GeneCards: EPC1 |
---|
|
|
Ontologija gena |
---|
Molekularna funkcija | • histone acetyltransferase activity • GO:0001948, GO:0016582 vezivanje za proteine
|
---|
Ćelijska komponenta | • Piccolo NuA4 histone acetyltransferase complex • Jedarna membrana • jedro • NuA4 histone acetyltransferase complex • nukleoplazma
|
---|
Biološki proces | • vascular associated smooth muscle cell differentiation • GO:0009373 regulation of transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • histone H4 acetylation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • histone H2A acetylation • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • transcription, DNA-templated • regulation of growth • negative regulation of gene expression, epigenetic • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of G0 to G1 transition • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization
|
---|
Izvori:Amigo / QuickGO |
|
Ortolozi |
---|
Vrste | Čovjek | Miš |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNK) | | |
---|
RefSeq (bjelančevina) | | |
---|
Lokacija (UCSC) | Chr 10: 32.27 – 32.38 Mb | Chr 18: 6.44 – 6.52 Mb |
---|
PubMed pretraga | [3] | [4] |
---|
Wikipodaci |
|
Zatvori
Dužina polipeptidnog lanca je 836 aminokiselina, а molekulska težina 93.463.[7]
10 | | 20 | | 30 | | 40 | | 50 |
MSKLSFRARA | | LDASKPLPVF | | RCEDLPDLHE | | YASINRAVPQ | | MPTGMEKEEE |
SEHHLQRAIS | | AQQVYGEKRD | | NMVIPVPEAE | | SNIAYYESIY | | PGEFKMPKQL |
IHIQPFSLDA | | EQPDYDLDSE | | DEVFVNKLKK | | KMDICPLQFE | | EMIDRLEKGS |
GQQPVSLQEA | | KLLLKEDDEL | | IREVYEYWIK | | KRKNCRGPSL | | IPSVKQEKRD |
GSSTNDPYVA | | FRRRTEKMQT | | RKNRKNDEAS | | YEKMLKLRRD | | LSRAVTILEM |
IKRREKSKRE | | LLHLTLEIME | | KRYNLGDYNG | | EIMSEVMAQR | | QPMKPTYAIP |
IIPITNSSQF | | KHQEAMDVKE | | FKVNKQDKAD | | LIRPKRKYEK | | KPKVLPSSAA |
ATPQQTSPAA | | LPVFNAKDLN | | QYDFPSSDEE | | PLSQVLSGSS | | EAEEDNDPDG |
PFAFRRKAGC | | QYYAPHLDQT | | GNWPWTSPKD | | GGLGDVRYRY | | CLTTLTVPQR |
CIGFARRRVG | | RGGRVLLDRA | | HSDYDSVFHH | | LDLEMLSSPQ | | HSPVNQFANT |
SETNTSDKSF | | SKDLSQILVN | | IKSCRWRHFR | | PRTPSLHDSD | | NDELSCRKLY |
RSINRTGTAQ | | PGTQTCSTST | | QSKSSSGSAH | | FAFTAEQYQQ | | HQQQLALMQK |
QQLAQIQQQQ | | ANSNSSTNTS | | QNLASNQQKS | | GFRLNIQGLE | | RTLQGFVSKT |
LDSASAQFAA | | SALVTSEQLM | | GFKMKDDVVL | | GIGVNGVLPA | | SGVYKGLHLS |
STTPTALVHT | | SPSTAGSALL | | QPSNITQTSS | | SHSALSHQVT | | AANSATTQVL |
IGNNIRLTVP | | SSVATVNSIA | | PINARHIPRT | | LSAVPSSALK | | LAAAANCQVS |
KVPSSSSVDS | | VPRENHESEK | | PALNNIADNT | | VAMEVT |
- Doyon Y, Côté J (2004). "The highly conserved and multifunctional NuA4 HAT complex". Curr. Opin. Genet. Dev. 14 (2): 147–54. doi:10.1016/j.gde.2004.02.009. PMID 15196461.
- Liedtke W, Meyer G, Faustmann PM, et al. (1997). "Clonal expansion and decreased occurrence of peripheral blood gamma delta T cells of the V delta 2J delta 3 lineage in multiple sclerosis patients". Int. Immunol. 9 (7): 1031–41. doi:10.1093/intimm/9.7.1031. PMID 9237112.
- Wang X, Stollar BD (1999). "Immunoglobulin VH gene expression in human aging". Clin. Immunol. 93 (2): 132–42. doi:10.1006/clim.1999.4781. PMID 10527689.
- Kenny TP, Semrad TJ, Malyj W, Robbins DL (2001). "Mutational analysis of immunoglobulin germline derived Vlambda4B light chains in rheumatoid arthritis". Clin. Immunol. 99 (2): 283–90. doi:10.1006/clim.2001.5020. PMID 11318600.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Cai Y, Jin J, Tomomori-Sato C, et al. (2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J. Biol. Chem. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Doyon Y, Selleck W, Lane WS, et al. (2004). "Structural and Functional Conservation of the NuA4 Histone Acetyltransferase Complex from Yeast to Humans". Mol. Cell. Biol. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC 350560. PMID 14966270.
- Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Attwooll C, Oddi S, Cartwright P, et al. (2005). "A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner". J. Biol. Chem. 280 (2): 1199–208. doi:10.1074/jbc.M412509200. PMID 15536069.
- Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. Biol. Chem. 280 (14): 13665–70. doi:10.1074/jbc.M500001200. PMID 15647280.
- Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
- Kee HJ, Kim JR, Nam KI, et al. (2007). "Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation". J. Biol. Chem. 282 (10): 7700–9. doi:10.1074/jbc.M611198200. PMID 17192267.