DNASE2

Lizosomska dezoksiribonukleaza II je protein koji je kod ljudi kodiran genom DNASE2.^[4]

DNASE2
Identifikatori
Aliasi	DNASE2
Vanjski ID-jevi	OMIM: 126350 MGI: 1329019 HomoloGene: 68179 GeneCards: DNASE2
Lokacija gena (čovjek) Hrom. Hromosom 19 (čovjek)[1] Bend 19p13.13 Početak 12,875,209 bp[1] Kraj 12,881,466 bp[1]
Ontologija gena Molekularna funkcija • vezivanje sa DNK • nuclease activity • endonuclease activity • endodeoxyribonuclease activity • hydrolase activity • deoxyribonuclease II activity Ćelijska komponenta • Lizozom • Egzosom • intracellular anatomical structure Biološki proces • erythrocyte differentiation • multicellular organism development • DNA metabolic process • DNA catabolic process • DNA catabolic process, endonucleolytic • GO:0097285 apoptoza • apoptotic DNA fragmentation • regulation of immune response Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	1777	13423
Ensembl	ENSG00000105612	ENSMUSG00000003812
UniProt	O00115	P56542
RefSeq (mRNK)	NM_001375	NM_010062 NM_001368295 NM_001368296
RefSeq (bjelančevina)	NP_001366 NP_001366.1	NP_034192 NP_001355224 NP_001355225
Lokacija (UCSC)	Chr 19: 12.88 – 12.88 Mb	n/a
PubMed pretraga	[2]	[3]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MIPLLLAALL		CVPAGALTCY		GDSGQPVDWF		VVYKLPALRG		SGEAAQRGLQ
YKYLDESSGG		WRDGRALINS		PEGAVGRSLQ		PLYRSNTSQL		AFLLYNDQPP
QPSKAQDSSM		RGHTKGVLLL		DHDGGFWLVH		SVPNFPPPAS		SAAYSWPHSA
CTYGQTLLCV		SFPFAQFSKM		GKQLTYTYPW		VYNYQLEGIF		AQEFPDLENV
VKGHHVSQEP		WNSSITLTSQ		AGAVFQSFAK		FSKFGDDLYS		GWLAAALGTN
LQVQFWHKTV		GILPSNCSDI		WQVLNVNQIA		FPGPAGPSFN		STEDHSKWCV
SPKGPWTCVG		DMNRNQGEEQ		RGGGTLCAQL		PALWKAFQPL		VKNYQPCNGM
ARKPSRAYKI

Funkcija

Ovaj gen kodira člana porodice DNaza. Protein koji se nalazi u lizosomima, hidrolizira DNK u kiselim uslovima i posreduje u njenom raspadanju tokom eritropoeze i apoptoze.

Okarakterizirana su dva kodominantna alelA, DNASE2 * L (niska aktivnost) i DNASE2 * H (visoka aktivnost), koji se razlikuju PO jednom nukleotidU u promotorskoj regiji. U ovom TRANSKRIPTU zastupljen je alel DNASE2 * H.

Reference

1. GRCh38: Ensembl release 89: ENSG00000105612 - Ensembl, maj 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: Deoxyribonuclease II, lysosomal". Pristupljeno 7. 9. 2016.

Dopunska literatura

• Chou SF, Chen HL, Lu SC (2002). "Up-regulation of human deoxyribonuclease II gene expression during myelomonocytic differentiation of HL-60 and THP-1 cells". Biochem. Biophys. Res. Commun. 296 (1): 48–53. doi:10.1016/s0006-291x(02)00835-5. PMID 12147225.