DDX59

Vjerovatno ATP-ovisna RNK-helikaza DDX59 jest enzim koji je kod ljudi kodiran genom DDX59 sa hromosoma 1.^[5]

DDX59
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2YQP
Identifikatori
Aliasi	DDX59
Vanjski ID-jevi	OMIM: 615464 MGI: 1915247 HomoloGene: 12222 GeneCards: DDX59
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek)[1] Bend 1q32.1 Početak 200,623,896 bp[1] Kraj 200,669,907 bp[1]
Lokacija gena (miš) Hrom. Hromosom 1 (miš)[2] Bend 1|1 E4 Početak 136,343,009 bp[2] Kraj 136,367,896 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • nucleotide binding • hydrolase activity • ATP binding • GO:0008026 helicase activity • vezivanje iona metala • vezivanje sa RNK • nucleic acid binding Ćelijska komponenta • intracellular anatomical structure • jedro • Jedarce • citoplazma • membrana • integral component of membrane Biološki proces • RNA secondary structure unwinding Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	83479	67997
Ensembl	ENSG00000118197	ENSMUSG00000026404
UniProt	Q5T1V6 Q5T1W1	Q9DBN9
RefSeq (mRNK)	NM_001031725 NM_031306 NM_001320181 NM_001320182 NM_001349799 NM_001349800 NM_001349801 NM_001349802 NM_001349803 NM_001349804	NM_026500 NM_178052
RefSeq (bjelančevina)	NP_001026895 NP_001307110 NP_001307111 NP_001336728 NP_001336729 NP_001336730 NP_001336731 NP_001336732 NP_001336733	NP_080776
Lokacija (UCSC)	Chr 1: 200.62 – 200.67 Mb	Chr 1: 136.34 – 136.37 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 619 aminokiselina, a molekulska težina 68.810 Da.^[6]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MFVPRSLKIK		RNANDDGKSC		VAKIIKPDPE		DLQLDKSRDV		PVDAVATEAA
TIDRHISESC		PFPSPGGQLA		EVHSVSPEQG		AKDSHPSEEP		VKSFSKTQRW
AEPGEPICVV		CGRYGEYICD		KTDEDVCSLE		CKAKHLLQVK		EKEEKSKLSN
PQKADSEPES		PLNASYVYKE		HPFILNLQED		QIENLKQQLG		ILVQGQEVTR
PIIDFEHCSL		PEVLNHNLKK		SGYEVPTPIQ		MQMIPVGLLG		RDILASADTG
SGKTAAFLLP		VIMRALFESK		TPSALILTPT		RELAIQIERQ		AKELMSGLPR
MKTVLLVGGL		PLPPQLYRLQ		QHVKVIIATP		GRLLDIIKQS		SVELCGVKIV
VVDEADTMLK		MGFQQQVLDI		LENIPNDCQT		ILVSATIPTS		IEQLASQLLH
NPVRIITGEK		NLPCANVRQI		ILWVEDPAKK		KKLFEILNDK		KLFKPPVLVF
VDCKLGADLL		SEAVQKITGL		KSISIHSEKS		QIERKNILKG		LLEGDYEVVV
STGVLGRGLD		LISVRLVVNF		DMPSSMDEYV		HQIGRVGRLG		QNGTAITFIN
NNSKRLFWDI		AKRVKPTGSI		LPPQLLNSPY		LHDQKRKEQQ		KDKQTQNDLV
TGANLMDIIR		KHDKSNSQK

Reference

1. GRCh38: Ensembl release 89: ENSG00000118197 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026404 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: DDX59 DEAD (Asp-Glu-Ala-Asp) box polypeptide 59".
6. "UniProt, Q5T1V6" (jezik: en.). Pristupljeno 9. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.

Vanjski linkovi