Ćelijskopovršinski transmembranski glikoproteinski CD200 receptor 1 jest protein koji je kod ljudi kodiran genom CD200R1 sa hromosoma 3.[5][6][7] CD200R1 se eksprimira na površini mijeloidnih ćelija [8] i CD4+ T-ćelija.[9] Interragira sa CD200 transmembranskim glikoproteinom koji se može eksprimirati na različitim ćelijama uključujući neurone,[10] epithelial cells,[11] endotelne ćelije,[12] fibroblaste,[13] i limfoidne ćelije.[14]
Kratke činjenice Dostupne strukture, PDB ...
Zatvori
Aktivacija CD200R1 regulira ekspresiju proupalnih molekula kao što je faktor tumorske nekroze (TNF-alfa),[15] interferoni i inducibilnadušik-oksidna sintetaza (iNOS).[16]
Dužina polipeptidnog lanca je 325 aminokiselina, а molekulska težina 36.620 Da.[17]
10 | | 20 | | 30 | | 40 | | 50 |
MLCPWRTANL | | GLLLILTIFL | | VAASSSLCMD | | EKQITQNYSK | | VLAEVNTSWP |
VKMATNAVLC | | CPPIALRNLI | | IITWEIILRG | | QPSCTKAYRK | | ETNETKETNC |
TDERITWVSR | | PDQNSDLQIR | | PVAITHDGYY | | RCIMVTPDGN | | FHRGYHLQVL |
VTPEVTLFQN | | RNRTAVCKAV | | AGKPAAQISW | | IPEGDCATKQ | | EYWSNGTVTV |
KSTCHWEVHN | | VSTVTCHVSH | | LTGNKSLYIE | | LLPVPGAKKS | | AKLYIPYIIL |
TIIILTIVGF | | IWLLKVNGCR | | KYKLNKTEST | | PVVEEDEMQP | | YASYTEKNNP |
LYDTTNKVKA | | SEALQSEVDT | | DLHTL |
Ovaj gen kodira receptor za OX-2 membranski glikoprotein. I receptor i supstrat su glikoproteini ćelijske površine koji sadrže dva imunoglobulinska domena. Ovaj receptor je ograničen na površine loze mijeloidnih ćelija i interakcija receptor-supstrat može funkcionirati kao mijeloidni regulatorni signal. Studije srodnog gena na miševima sugeriraju da ova interakcija može kontrolirati mijeloidnu funkciju na tkivno specifičan način. Alternativna prerada ovog gena rezultira višestrukim varijantama transkripta.[7]
Ishibashi M, Neri S, Hashimoto H, Miyashita T, Yoshida T, Nakamura Y, Udagawa H, Kirita K, Matsumoto S, Umemura S, Yoh K, Niho S, Tsuboi M, Masutomi K, Goto K, Ochiai A, Ishii G (april 2017). "CD200-positive cancer associated fibroblasts augment the sensitivity of Epidermal Growth Factor Receptor mutation-positive lung adenocarcinomas to EGFR Tyrosine kinase inhibitors". Scientific Reports. 7: 46662. Bibcode:2017NatSR...746662I. doi:10.1038/srep46662. PMC 5399371. PMID 28429795. Gentry M, Bodo J, Durkin L, Hsi ED (februar 2017). "Performance of a Commercially Available MAL Antibody in the Diagnosis of Primary Mediastinal Large B-Cell Lymphoma". The American Journal of Surgical Pathology. 41 (2): 189–194. doi:10.1097/PAS.0000000000000771. PMID 27879516. S2CID 25206581.
- Matsue H (decembar 2005). "CD 200-mediated regulation of skin immunity". The Journal of Investigative Dermatology. 125 (6): x–xi. doi:10.1111/j.0022-202X.2005.23978.x. PMID 16354172.
- Shiratori I, Yamaguchi M, Suzukawa M, Yamamoto K, Lanier LL, Saito T, Arase H (oktobar 2005). "Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200". Journal of Immunology. 175 (7): 4441–9. doi:10.4049/jimmunol.175.7.4441. PMID 16177086.
- Cherwinski HM, Murphy CA, Joyce BL, Bigler ME, Song YS, Zurawski SM, Moshrefi MM, Gorman DM, Miller KL, Zhang S, Sedgwick JD, Phillips JH (februar 2005). "The CD200 receptor is a novel and potent regulator of murine and human mast cell function". Journal of Immunology. 174 (3): 1348–56. doi:10.4049/jimmunol.174.3.1348. PMID 15661892.
- Zhang Z, Henzel WJ (oktobar 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
- Foster-Cuevas M, Wright GJ, Puklavec MJ, Brown MH, Barclay AN (juli 2004). "Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor". Journal of Virology. 78 (14): 7667–76. doi:10.1128/JVI.78.14.7667-7676.2004. PMC 434103. PMID 15220441.
- Karteris E, Chen J, Randeva HS (april 2004). "Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system". The Journal of Clinical Endocrinology and Metabolism. 89 (4): 1957–62. doi:10.1210/jc.2003-031778. PMID 15070969.
- Wright GJ, Cherwinski H, Foster-Cuevas M, Brooke G, Puklavec MJ, Bigler M, Song Y, Jenmalm M, Gorman D, McClanahan T, Liu MR, Brown MH, Sedgwick JD, Phillips JH, Barclay AN (septembar 2003). "Characterization of the CD200 receptor family in mice and humans and their interactions with CD200". Journal of Immunology. 171 (6): 3034–46. doi:10.4049/jimmunol.171.6.3034. PMID 12960329.
- Vieites JM, de la Torre R, Ortega MA, Montero T, Peco JM, Sánchez-Pozo A, Gil A, Suárez A (juni 2003). "Characterization of human cd200 glycoprotein receptor gene located on chromosome 3q12-13". Gene. 311: 99–104. doi:10.1016/S0378-1119(03)00562-6. PMID 12853143.