ARL6IP1

ADP-ribozilacijski faktoroliki protein 1 koji komunicira sa proteinom 6 jest protein koji je kod ljudi kodiran genom ARL6IP1.^[5]

ARL6IP1
Identifikatori
Aliasi	ARL6IP1
Vanjski ID-jevi	OMIM: 607669 MGI: 1858943 HomoloGene: 41008 GeneCards: ARL6IP1
Lokacija gena (čovjek) Hrom. Hromosom 16 (čovjek)[1] Bend 16p12.3 Početak 18,791,669 bp[1] Kraj 18,801,572 bp[1]
Lokacija gena (miš) Hrom. Hromosom 7 (miš)[2] Bend 7|7 F1 Početak 117,718,114 bp[2] Kraj 117,728,885 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje identičnih proteina Ćelijska komponenta • citoplazma • citosol • membrana • Sec61 translocon complex • Endoplazmatski retikulum • Endomembranski sistem • endoplasmic reticulum membrane • integral component of endoplasmic reticulum membrane • integral component of membrane Biološki proces • cotranslational protein targeting to membrane • endoplasmic reticulum tubular network formation • GO:0097285 apoptoza • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • endoplasmic reticulum tubular network membrane organization • negative regulation of apoptotic process • positive regulation of L-glutamate import across plasma membrane Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	23204	54208
Ensembl	ENSG00000170540	ENSMUSG00000030654
UniProt	Q15041	Q9JKW0
RefSeq (mRNK)	NM_015161 NM_001313858	NM_019419
RefSeq (bjelančevina)	NP_001300787 NP_055976	NP_062292
Lokacija (UCSC)	Chr 16: 18.79 – 18.8 Mb	Chr 7: 117.72 – 117.73 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 203 aminokiseline, a molekulska težina 23.363 Da.^[6]

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin

P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MAEGDNRSTN		LLAAETASLE		EQLQGWGEVM		LMADKVLRWE		RAWFPPAIMG
VVSLVFLIIY		YLDPSVLSGV		SCFVMFLCLA		DYLVPILAPR		IFGSNKWTTE
QQQRFHEICS		NLVKTRRRAV		GWWKRLFTLK		EEKPKMYFMT		MIVSLAAVAW
VGQQVHNLLL		TYLIVTSLLL		LPGLNQHGII		LKYIGMAKRE		INKLLKQKEK
KNE

Reference

1. GRCh38: Ensembl release 89: ENSG00000170540 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030654 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1".
6. "UniProt, Q15041". Pristupljeno 1. 7. 2021.

Vanjski linkovi

• Lokacija ljudskog genoma ARL6IP1 i stranica sa detaljima o genu ARL6IP1 u UCSC Genome Browseru.

Dopunska literatura

• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Lui HM, Chen J, Wang L, Naumovski L (2003). "ARMER, apoptotic regulator in the membrane of the endoplasmic reticulum, a novel inhibitor of apoptosis". Mol. Cancer Res. 1 (7): 508–18. PMID 12754298.
• Pettersson M, Bessonova M, Gu HF, Groop LC, Jönsson JI (2000). "Characterization, chromosomal localization, and expression during hematopoietic differentiation of the gene encoding Arl6ip, ADP-ribosylation-like factor-6 interacting protein (ARL6)". Genomics. 68 (3): 351–4. doi:10.1006/geno.2000.6278. PMID 10995579.
• Ingley E, Williams JH, Walker CE, Tsai S, Colley S, Sayer MS, Tilbrook PA, Sarna M, Beaumont JG, Klinken SP (1999). "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit". FEBS Lett. 459 (1): 69–74. doi:10.1016/S0014-5793(99)01188-6. PMID 10508919. S2CID 30948975.
• Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.