Angiopoetinu-srodni protein 1, znan i kao angiopoetin-3 (ANG-3) jest protein koji je kod ljudi kodiran genom ANGPTL1 sa hromosoma 1.[5][6][7]
Kratke činjenice Identifikatori, Aliasi ...
Zatvori
Dužina polipeptidnog lanca je 491 aminokiselina, a molekulska težina 56.720 Da.[8]
10 | | 20 | | 30 | | 40 | | 50 |
MKTFTWTLGV | | LFFLLVDTGH | | CRGGQFKIKK | | INQRRYPRAT | | DGKEEAKKCA |
YTFLVPEQRI | | TGPICVNTKG | | QDASTIKDMI | | TRMDLENLKD | | VLSRQKREID |
VLQLVVDVDG | | NIVNEVKLLR | | KESRNMNSRV | | TQLYMQLLHE | | IIRKRDNSLE |
LSQLENKILN | | VTTEMLKMAT | | RYRELEVKYA | | SLTDLVNNQS | | VMITLLEEQC |
LRIFSRQDTH | | VSPPLVQVVP | | QHIPNSQQYT | | PGLLGGNEIQ | | RDPGYPRDLM |
PPPDLATSPT | | KSPFKIPPVT | | FINEGPFKDC | | QQAKEAGHSV | | SGIYMIKPEN |
SNGPMQLWCE | | NSLDPGGWTV | | IQKRTDGSVN | | FFRNWENYKK | | GFGNIDGEYW |
LGLENIYMLS | | NQDNYKLLIE | | LEDWSDKKVY | | AEYSSFRLEP | | ESEFYRLRLG |
TYQGNAGDSM | | MWHNGKQFTT | | LDRDKDMYAG | | NCAHFHKGGW | | WYNACAHSNL |
NGVWYRGGHY | | RSKHQDGIFW | | AEYRGGSYSL | | RAVQMMIKPI | | D |
Angiopoetini su članovi porodice faktora rasta vaskularnog endotela i jedini poznati faktori rasta koji su uglavnom specifični za vaskularni endotel. Angiopoetin-1, angiopoetin-2 i angiopoetin-4 učestvuju u formiranju krvnih sudova.
Protein kodiran ovim genom je još jedan član porodice angiopoetina koji je široko eksprimiran u tkivima odraslih s najvišim nivoima iRNK u visoko vaskulariziranim tkivima. Utvrđeno je da je ovaj protein sekretorni protein koji ne djeluje kao endotelni mitogen in vitro.[7]
Lemmens I, Merregaert J, Van de Ven WJ, Kas K, Zhang CX, Giraud S, Wautot V, Buisson N, De Witte K, Salandre J, Lenoir G, Calender A, Parente F, Quincey D, Courseaux A, Carle GF, Gaudray P, De Wit MJ, Lips CJ, Hoppener JW, Khodaei S, Grant AL, Weber G, Kytola S, Thakker RV, et al. (Nov 1997). "Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1". Genomics. 44 (1): 94–100. doi:10.1006/geno.1997.4872. PMID 9286704.
- Dhanabal M, Jeffers M, LaRochelle WJ, Lichenstein HS (2005). "Angioarrestin: a unique angiopoietin-related protein with anti-angiogenic properties". Biochem. Biophys. Res. Commun. 333 (2): 308–15. doi:10.1016/j.bbrc.2005.05.134. PMID 15950186.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Valenzuela DM, Griffiths JA, Rojas J, et al. (1999). "Angiopoietins 3 and 4: diverging gene counterparts in mice and humans". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1904–9. Bibcode:1999PNAS...96.1904V. doi:10.1073/pnas.96.5.1904. PMC 26709. PMID 10051567.
- Avram D, Ishmael JE, Nevrivy DJ, et al. (1999). "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2". J. Biol. Chem. 274 (20): 14331–6. doi:10.1074/jbc.274.20.14331. PMC 2823254. PMID 10318855.
- Kim I, Moon SO, Koh KN, et al. (1999). "Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting". J. Biol. Chem. 274 (37): 26523–8. doi:10.1074/jbc.274.37.26523. PMID 10473614.
- Zeng L, Dai J, Ying K, et al. (2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart". J. Hum. Genet. 48 (3): 159–62. doi:10.1007/s100380300025. PMID 12624729.
- Lee HJ, Cho CH, Hwang SJ, et al. (2005). "Biological characterization of angiopoietin-3 and angiopoietin-4". FASEB J. 18 (11): 1200–8. doi:10.1096/fj.03-1466com. PMID 15284220. S2CID 19001234.
- Oliner J, Min H, Leal J, et al. (2004). "Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2". Cancer Cell. 6 (5): 507–16. doi:10.1016/j.ccr.2004.09.030. PMID 15542434.
- Smagur A, Szary J, Szala S (2006). "Recombinant angioarrestin secreted from mouse melanoma cells inhibits growth of primary tumours". Acta Biochim. Pol. 52 (4): 875–9. doi:10.18388/abp.2005_3401. PMID 15940350.