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Angiomotinoliki protein 2 jest protein koji je kod ljudi kodiran genom AMOTL2 sa hromosoma 3.[5]
Dužina polipeptidnog lanca je 779 aminokiselina, а molekulska težina 85.764 Da.[6]
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MRTLEDSSGT | VLHRLIQEQL | RYGNLTETRT | LLAIQQQALR | GGAGTGGTGS | ||||
PQASLEILAP | EDSQVLQQAT | RQEPQGQEHQ | GGENHLAENT | LYRLCPQPSK | ||||
GEELPTYEEA | KAHSQYYAAQ | QAGTRPHAGD | RDPRGAPGGS | RRQDEALREL | ||||
RHGHVRSLSE | RLLQLSLERN | GARAPSHMSS | SHSFPQLARN | QQGPPLRGPP | ||||
AEGPESRGPP | PQYPHVVLAH | ETTTAVTDPR | YRARGSPHFQ | HAEVRILQAQ | ||||
VPPVFLQQQQ | QYQYLQQSQE | HPPPPHPAAL | GHGPLSSLSP | PAVEGPVSAQ | ||||
ASSATSGSAH | LAQMEAVLRE | NARLQRDNER | LQRELESSAE | KAGRIEKLES | ||||
EIQRLSEAHE | SLTRASSKRE | ALEKTMRNKM | DSEMRRLQDF | NRDLRERLES | ||||
ANRRLASKTQ | EAQAGSQDMV | AKLLAQSYEQ | QQEQEKLERE | MALLRGAIED | ||||
QRRRAELLEQ | ALGNAQGRAA | RAEEELRKKQ | AYVEKVERLQ | QALGQLQAAC | ||||
EKREQLELRL | RTRLEQELKA | LRAQQRQAGA | PGGSSGSGGS | PELSALRLSE | ||||
QLREKEEQIL | ALEADMTKWE | QKYLEERAMR | QFAMDAAATA | AAQRDTTLIR | ||||
HSPQPSPSSS | FNEGLLTGGH | RHQEMESRLK | VLHAQILEKD | AVIKVLQQRS | ||||
RRDPGKAIQG | SLRPAKSVPS | VFAAAAAGTQ | GWQGLSSSER | QTADAPARLT | ||||
TDRAPTEEPV | VTAPPAAHAK | HGSRDGSTQT | EGPPDSTSTC | LPPEPDSLLG | ||||
CSSSQRAASL | DSVATSRVQD | LSDMVEILI |
Angiomotin je protein koji veže angiostatin, cirkulirajući inhibitor stvaranja novih krvnih sudova (angiogeneza). Angiomotin posreduje angiostatinom u inhibiciji migracije endotelnih ćelija i formiranja mikrotubula in vitro. Protein koji je kodiran ovim genom povezan je sa angiomotinom i član je porodice proteinskih motina.[5]
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