Adiponektinski receptor 1 (AdipoR1) jest protein koji je kod ljudi kodiran genom ADIPOR1 sa hromosoma 1.[5] Član je porodice progestini i adipoQ receptori (PAQR), a poznat je i kao PAQR1.[6]
Kratke činjenice Dostupne strukture, PDB ...
Zatvori
Dužina polipeptidnog lanca je 375 aminokiselina, a molekulska težina 42.616 Da.[7]
| 10 | | 20 | | 30 | | 40 | | 50 |
|---|
| MSSHKGSVVA | | QGNGAPASNR | | EADTVELAEL | | GPLLEEKGKR | | VIANPPKAEE |
| EQTCPVPQEE | | EEEVRVLTLP | | LQAHHAMEKM | | EEFVYKVWEG | | RWRVIPYDVL |
| PDWLKDNDYL | | LHGHRPPMPS | | FRACFKSIFR | | IHTETGNIWT | | HLLGFVLFLF |
| LGILTMLRPN | | MYFMAPLQEK | | VVFGMFFLGA | | VLCLSFSWLF | | HTVYCHSEKV |
| SRTFSKLDYS | | GIALLIMGSF | | VPWLYYSFYC | | SPQPRLIYLS | | IVCVLGISAI |
| IVAQWDRFAT | | PKHRQTRAGV | | FLGLGLSGVV | | PTMHFTIAEG | | FVKATTVGQM |
| GWFFLMAVMY | | ITGAGLYAAR | | IPERFFPGKF | | DIWFQSHQIF | | HVLVVAAAFV |
| HFYGVSNLQE | | FRYGLEGGCT | | DDTLL |
Slično G-protein spregnutim receptorima (GPCR), AdipoR1 također ima sedam transmembranskih domena. Međutim, AdipoR1 je orijentiran suprotno od GPCR u membrani (tj., citoplazmatski N-terminal, vanćelijski C-terminal) i ne povezuje se sa G-proteinima.[5]
Adiponektinski receptori, AdipoR1 i AdipoR2, služe kao receptori za globulasti i punodužinski adiponektin i posreduju u povećanju razine AMP-aktivirane protein-kinaze (AMPK) i PPAR-α aktivnosti liganda, kao i oksidaciji masnih kiselima i uzimanju glukoze za adiponektin.[5][8] Univerzitet u Tokiju je 2016. objavio da pokreće istragu o anonimnim tvrdnjama o izmišljenim i falsifikovanim podacima o identifikaciji AdipoR1 i AdipoR2.[9]
- Adiponektinski receptor
- Adiponektinski receptor 2
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