Sigma receptor
Class of cell surface receptors / From Wikipedia, the free encyclopedia
Sigma receptors (σ-receptors) are protein receptors that bind ligands such as 4-PPBP (4-phenyl-1-(4-phenylbutyl) piperidine),[1] SA 4503 (cutamesine), ditolylguanidine, dimethyltryptamine,[2] and siramesine.[3] There are two subtypes, sigma-1 receptors (σ1) and sigma-2 receptors (σ2), which are classified as sigma receptors for their pharmacological similarities, even though they are evolutionarily unrelated.
![]() | This article may be too technical for most readers to understand. (August 2020) |
Quick Facts ERG2/Sigma-1 receptor, Identifiers ...
ERG2/Sigma-1 receptor | |||||||||
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Identifiers | |||||||||
Symbol | ERG2_Sigma1R | ||||||||
Pfam | PF04622 | ||||||||
InterPro | IPR006716 | ||||||||
TCDB | 8.A.63 | ||||||||
OPM superfamily | 446 | ||||||||
OPM protein | 5hk1 | ||||||||
Membranome | 1025 | ||||||||
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The fungal protein ERG2, a C-8 sterol isomerase, falls into the same protein family as sigma-1. Both localize to the ER membrane, although sigma-1 is also reported to be a cell surface receptor. Sigma-2 is an EXPREA domain protein[4] with a mostly intracellular (ER membrane) localization.[5]