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4-PPBP
Chemical compound / From Wikipedia, the free encyclopedia
4-PPBP is a neuroprotective cyclic amine which binds to sigma receptors.[1]
Quick Facts Names, Identifiers ...
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Names | |
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Preferred IUPAC name
4-Phenyl-1-(4-phenylbutyl)piperidine | |
Identifiers | |
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MeSH | 4-phenyl-1-(4-phenylbutyl)piperidine |
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CompTox Dashboard (EPA) |
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Properties | |
C21H27N | |
Molar mass | 293.446 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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4-PPBP decreases neuronal nitric oxide synthase (nNOS) activity and ischemia-evoked nitric oxide (NO) production. 4-PPBP provides neuroprotection; this involves the prevention of ischemia-induced intracellular Ca2+ dysregulation.[2] 4-PPBP protects neurons using a mechanism that activates the transcription factor cyclic adenosine monophosphate response element-binding protein (CREB). Neuroprotection that is associated with 4-PPBP increases Bcl-2 expression; Bcl-2 expression is regulated by CREB.[3]