Cutamesine
Chemical compound / From Wikipedia, the free encyclopedia
Cutamesine (SA 4503) is a synthetic sigma receptor agonist which is selective for the σ1 receptor, a chaperone protein mainly found in the endoplasmic reticulum of cells in the central nervous system.[1][2][3][4] These σ1 receptors play a key role in the modulation of Ca2+ release and apoptosis.[3] Cutamesine's activation of the σ1 receptor is tied to a variety of physiological phenomena in the CNS, including activation of dopamine-releasing neurons and repression of the MAPK/ERK pathway.[5][6]
Quick Facts Names, Identifiers ...
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Preferred IUPAC name
1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine | |
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3D model (JSmol) |
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CompTox Dashboard (EPA) |
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Properties | |
C23H32N2O2 | |
Molar mass | 368.521 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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