內皮PAS結構域包含蛋白-1(英語:Endothelial PAS domain-containing protein 1,縮寫EPAS1,也被稱為缺氧誘導因子-2α亞基,英語:Hypoxia-inducible factor-2alpha,縮寫HIF-2α)是一種由人類基因 EPAS1 所編碼的蛋白質[6][7][8][9]。
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EPAS1所表現的蛋白是一個轉錄因子的組成部分,該轉錄因子介導一些受氧氣調控基因的表現,特別是低氧(缺氧)環境下。該蛋白包含一個鹼性螺旋-環-螺旋蛋白二聚化結構域,此結構域也常見於其它氧應激相關信號通路蛋白。EPAS1涉及胚胎心臟的發育,並在臍帶的血管壁內皮細胞中表現。EPAS1維持兒茶酚胺類物質在胚胎早期發育中的穩定,以防止心臟衰竭[9]。兒茶酚胺類物質包括腎上腺素和正腎上腺素,其穩定對胎兒與成人的心臟的健康有著重要作用[10]。
EPAS1能與芳香烴受體核轉位子[7]和ARNTL[11]發生交互作用。
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Hogenesch JB, Chan WK, Jackiw VH, Brown RC, Gu YZ, Pray-Grant M, Perdew GH, Bradfield CA. Characterization of a subset of the basic helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J Biol Chem. May 1997, 272 (13): 8581–93. PMID 9079689. doi:10.1074/jbc.272.13.8581.
Percy MJ, Beer PA, Campbell G, Dekker AW, Green AR, Oscier D, Rainey MG, van Wijk R, Wood M, Lappin TR, McMullin MF, Lee FS. Novel exon 12 mutations in the HIF2A gene associated with erythrocytosis. Blood. May 2008, 111 (11): 5400–2. PMC 2396730
. PMID 18378852. doi:10.1182/blood-2008-02-137703.
EPAS1引用了美國國家醫學圖書館提供的資料,這些資料屬於公共領域。
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