VCAM-1
位於1號人類染色體的基因 / 維基百科,自由的 encyclopedia
VCAM-1(Vascular cell adhesion protein 1(I型血管細胞黏附蛋白)),又稱CD106,是一種細胞黏附蛋白,在人體內由VCAM-1基因編碼,屬於一種唾液酸醣蛋白[5]。
結構
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VCAM-1含有6個或7個免疫球蛋白結構域,屬於免疫球蛋白蛋白超家族(英語:Protein superfamily)(IgSF)。於人體內存在兩個由可變剪接產生的轉錄本[6]。
功能與分佈
VCAM-1參與淋巴球—內皮細胞間黏附過程和細胞間信號識別過程,能在免疫應答中促進淋巴球向發炎區遷移[7]。淋巴球、軟骨細胞等細胞中都含有VCAM-1,血管內皮細胞在受到細胞因子刺激後也會表達VCAM-1蛋白[6][8]。一些間充質幹細胞亞群細胞表面表達CD106(VCAM-1)[9]。
參考
- Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- Cybulsky M, Fries JW, Williams AJ, Sultan P, Eddy RL, Byers MG, Shows TB, Gimbrone MA Jr, Collins T. The human VCAM1 gene is assigned to chromosome 1p31-p32. Cytogenet. Cell Genet. 1991, 58: 1852. doi:10.1159/000133735.
- Kienzle G.; von Kempis J. Vascular cell adhesion molecule 1 (CD106) on primary human articular chondrocytes: functional regulation of expression by cytokines and comparison with intercellular adhesion molecule 1 (CD54) and very late activation antigen 2. Arthritis Rheum. 1998 Jul;41(7):1296-305.